MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL FEATURES OF PLACENTAL DAMAGE DUE TO THE INCORPORATION OF 137Cs.

Objective: to investigate the morphological and immunohistochemical features of placental damage due to theincorporation of 137Cs depending on the scenario of pregnancy completion.

Materials And Methods: The study material consisted of placentas from 60 women with reproductive losses inanamnesis and signs of termination of the current pregnancy (first group) and placental samples from 30 women with an uncomplicated gestation and an unencumbered anamnesis (control group). The detailed study required the distribution of placental samples from the first group into subgroups.

[Venous forms of the inborn vascular malformations of the lower extremities. Diagnosis and surgical treatment].

Pathogenetically substantiated approach, using surgical, laser and echosclerosing methods, was applied for improvement of the treatment results in patients, suffering venous forms of the inborn vascular malformations of the lower extremities. The results of examination and treatment in 2006-2009 period were analyzed in 98 patients. The stem malformations with superficial venous system affection was diagnosed in 59 (60.

[Changes of ultrastructure of the capillary endotheliocytes of ischemized and nonaffected muscular tissue after transplantation of human hemopoietic stem cells of fetal liver in experiment in vivo].

In experiment was investigated ultrastructure of the capillaries endothelial cells and histological peculiarities of muscular tissue on various stages after transplantation of hemopoietic stem cells of fetal liver (HSCFL). There was proved, that in ischemic environment HSCFL stimulate processes of angiogenesis, and in the case of transplantation into intact muscular tissue they are differentiating into the tissue macrophages, not interfering with muscular tissue structure.

[Changes of the brain stem neurocytes in newborn rats in the conditions of experimental model of hypoxia during neuroprotective correction].

The work includes a research of morphological and immune-histochemical specifics of baby rats' cerebral structures in the conditions of experimental hypoxia model and with the administration of Cerebrocurin. It was ascertained that the most pronounced changes in the form of pericellular and perivascular edema, spongiform loci and loci of necrosis, with the phenomena of apoptosis and aponeuroses, occurred during severe hypoxia. Administration of Cerebrocurin in baby rats, which experienced moderate hypoxia, causes a decrease in pathological changes in cerebral structures and the approximation of the level of CD95 APO-1/Fas and Bcl-21 gene expression to their level in intact animals.

[The structural characteristics of the placental barrier during the dynamics of pregnancy in women over 35].

Biopsy of chorion early in the course of pregnancy is of great diagnostic value. Morphological, electron microscopic, and morphometric findings for the shaggy chorion during the I to II trimesters of pregnancy show that in women aged 35 to 45 years with physiological pregnancy changes occur in all structures of the placental barrier as compared to young women. During the I and II trimesters of pregnancy, those women who range from 35 to 45 years old exhibit disturbances in the processes of chorion vascularization, with the compensatory and adaptive reactions developing on the cellular and subcellular levels.

[The morphological and cytogenetic aspects in a study of chorionic and placental biopsies in pregnant women who are over the age of 35].

Perinatal pathology and morbidity takes the leading role in children pathology and morbidity today. These indices are of significance for the pregnant women of high risk group pregnant women in the age of 35 and above occupying peculiar place in this group. In this connection the morphological studies of chorion and placenta biopsies in this group of patients are important and urgent.