Publications by authors named "Zadid Haq"
Article Synopsis
- * A systematic review and meta-analysis included 34 studies, analyzing responses from various biologics: infliximab showed the highest complete response rates in chronic antibiotic-refractory pouchitis (CARP) and Crohn's disease (CD) of the pouch.
- * Results indicated different efficacy among biologics, with infliximab performing best for CARP, while patient responses varied for other agents like adalimumab, ustekinumab, and vedolizumab, highlighting the
Efficacy and safety of biologic therapy in microscopic colitis: systematic review and meta-analysis.
Eur J Gastroenterol Hepatol
October 2022
Article Synopsis
- This systematic review and meta-analysis assessed the effectiveness and safety of biologic therapies for patients with steroid-refractory microscopic colitis (MC).
- A total of 376 studies were screened, resulting in 13 articles focused on 78 patients, showing remission rates of approximately 66% at 3-6 weeks and 54% at 12-16 weeks, with a 100% clinical response rate initially but a drop to around 67% later on.
- The study found a significant incidence of medication discontinuation (16.1%) as the most common adverse event, and concluded that while there is low-quality evidence supporting the short-term use of biologics, more rigorous research is needed to clarify their long-term efficacy
Background: Perianal Crohn's disease (pCD) is a debilitating complication affecting up to 30% of Crohn's disease (CD) population, leading to increased morbidity, mortality and decreased quality of life. Despite the growing armamentarium of medications for luminal CD, their efficacy in pCD remains poorly studied.
Aim: To determine the efficacy of ustekinumab, a biologic approved for luminal CD, in pCD through a retrospective cohort study and systematic review.
Background: The objective of our systematic review and meta-analysis was to evaluate the effectiveness and safety of tofacitinib in the treatment of moderate-severe ulcerative colitis (UC).
Methods: We searched Medline, Embase, Web of Science, and Cochrane Central to identify articles and abstracts reporting efficacy or safety data on tofacitinib use in UC. Primary outcome assessed was remission.
A dilated gastrojejunal anastomosis (GJA) diameter is an independent predictor of weight regain following Roux-en-Y gastric bypass (RYGB). Despite this, there is no standardized method for GJA diameter measurement. We performed a retrospective analysis to compare endoscopic visual estimation and endoluminal functional impedance planimetry (EndoFLIP) for measuring GJA diameter in patients with weight regain post-RYGB.
View Article and Find Full Text PDFBackground: The double purse-string pattern (DPSP) of transoral outlet reduction (TORe) should conceivably result in a more robust scaffolding for the gastrojejunal anastomosis (GJA). However, there is a paucity of literature pertaining to post-TORe stenosis as an adverse event. Our aim was to determine the rate of stenosis, its potential predictors, and other complications of DPSP TORe.
View Article and Find Full Text PDFEndobariatrics and Metabolic Endoscopy: Can We Solve the Obesity Epidemic with Our Scope?
Curr Gastroenterol Rep
November 2020
Purpose Of Review: Obesity is a chronic relapsing disease that results in cardiovascular disease, diabetes mellitus, and non-alcoholic fatty liver disease. Currently, surgery represents the most effective treatment. However, the advent of minimally invasive endoscopic bariatric therapy (EBT) has shifted the treatment paradigm to less invasive, cost-effective procedures with minimal complications and recovery time that are preferred by patients.
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