Evaluation of levocetirizine in beagle dog and cynomolgus monkey telemetry assays: Defining the no QTc effect profile by timepoint and concentration-QTc analysis.

In prior clinical studies, levocetirizine (LEVO) has demonstrated no effect on ventricular repolarization (QTc intervals), therefore it is a relevant negative control to assess in nonclinical assays to define low proarrhythmic risk. LEVO was tested in beagle dog and cynomolgus monkey (nonhuman primate [NHP]) telemetry models to understand the nonclinical-clinical translation of this negative control. One oral dose of vehicle, LEVO (10 mg/kg/species) or moxifloxacin (MOXI; 30 mg/kg/dog; 80 mg/kg/NHP) was administered to instrumented animals (N = 8/species) using a cross-over dosing design; MOXI was the in-study positive control.

Relative Contributions of Social, Contextual, and Lexical Factors in Speech Processing.

This exploratory study examined the simultaneous interactions and relative contributions of bottom-up social information (regional dialect, speaking style), top-down contextual information (semantic predictability), and the internal dynamics of the lexicon (neighborhood density, lexical frequency) to lexical access and word recognition. Cross-modal matching and intelligibility in noise tasks were conducted with a community sample of adults at a local science museum. Each task featured one condition in which keywords were presented in isolation and one condition in which they were presented within a multiword phrase.

Evaluation of moxifloxacin in canine and non-human primate telemetry assays: Comparison of QTc interval prolongation by timepoint and concentration-QTc analysis.

The in vivo correct QT (QTc) assay is used by the pharmaceutical industry to characterize the potential for delayed ventricular repolarization and is a core safety assay mentioned in International Conference on Harmonization (ICH) S7B guideline. The typical telemetry study involves a dose-response analysis of QTc intervals over time using a crossover (CO) design. This method has proven utility but does not include direct integration of pharmacokinetic (PK) data.

Scapular muscles strength in college baseball players with and without a history of UCL injury.

Background: Ulnar collateral ligament (UCL) injuries are common in overhead athletes and have increased in prevalence among baseball pitchers of all ages. The purpose of this study was to examine the difference between the strength of five scapular stabilizing muscles in college baseball pitchers with and without a history of UCL surgery. Data on a pitcher with a recent diagnosis of a Grade I UCL sprain was also included as a case study.

Subphonemic Variation and Lexical Processing: Social and Stylistic Factors.

Different pronunciation variants of the same word can facilitate lexical access, but they may be more or less effective primes depending on their phonological form, stylistic appropriateness, familiarity, and social prestige, suggesting that multiple phonological variants are encoded in the lexicon with varying strength. The current study investigated how subphonemic variation is encoded using a lexical decision task with cross-modal form priming. The results revealed that the magnitude of priming was mediated by stylistic and social properties of the auditory primes, including speaking style, talker dialect, and duration.

A drift-diffusion checkpoint model predicts a highly variable and growth-factor-sensitive portion of the cell cycle G1 phase.

Even among isogenic cells, the time to progress through the cell cycle, or the intermitotic time (IMT), is highly variable. This variability has been a topic of research for several decades and numerous mathematical models have been proposed to explain it. Previously, we developed a top-down, stochastic drift-diffusion+threshold (DDT) model of a cell cycle checkpoint and showed that it can accurately describe experimentally-derived IMT distributions [Leander R, Allen EJ, Garbett SP, Tyson DR, Quaranta V.