Publications by authors named "Zachlyn N Farwig"
The main focus of the serum amyloid A (SAA) family has been on the acute phase isoforms. However, the constitutive isoform (SAA4) may have a strong effect on the metabolism of human serum lipoproteins. In this study, the SAA4 protein was examined in the high-density lipoprotein fraction of both healthy and diseased individuals.
View Article and Find Full Text PDFContext: Low birth weight is associated with increased cardiovascular disease in adulthood, and differences in the molecular weight, composition, and quantity of lipoprotein subclasses are associated with coronary artery disease.
Objective: To determine if there are novel patterns of lipoprotein heterogeneity in low-birth-weight infants.
Design, Setting, And Participants: Prospective study at a US medical center of a representative sample of infants (n = 163; 70 white and 93 black) born at 28 or more weeks of gestational age between January 3, 2000, and September 27, 2000.
Article Synopsis
- The proteins tied to lipoproteins in the blood are crucial for lipid metabolism and structural stability; any alterations can lead to cardiovascular issues.
- Researchers utilized high-resolution techniques, namely pI measurement and MALDI analysis, to effectively analyze apolipoproteins from HDL found in serum.
- The study successfully produced the first detailed pI profile of HDL apolipoproteins and highlighted the innovative method of linking pI profiles with molecular weight determination via MALDI, enabling better characterization of these complex proteins.