Evolution of Transcript Abundance is Influenced by Indels in Protein Low Complexity Regions.

Protein Protein low complexity regions (LCRs) are compositionally biased amino acid sequences, many of which have significant evolutionary impacts on the proteins which contain them. They are mutationally unstable experiencing higher rates of indels and substitutions than higher complexity regions. LCRs also impact the expression of their proteins, likely through multiple effects along the path from gene transcription, through translation, and eventual protein degradation.

Low Complexity Regions in Proteins and DNA are Poorly Correlated.

Low complexity sequences (LCRs) are well known within coding as well as non-coding sequences. A low complexity region within a protein must be encoded by the underlying DNA sequence. Here, we examine the relationship between the entropy of the protein sequence and that of the DNA sequence which encodes it.

Erratum: Probe design for simultaneous, targeted capture of diverse metagenomic targets.

[This corrects the article DOI: 10.1016/j.crmeth.

Low Complexity Regions in Mammalian Proteins are Associated with Low Protein Abundance and High Transcript Abundance.

Low Complexity Regions (LCRs) are present in a surprisingly large number of eukaryotic proteins. These highly repetitive and compositionally biased sequences are often structurally disordered, bind promiscuously, and evolve rapidly. Frequently studied in terms of evolutionary dynamics, little is known about how LCRs affect the expression of the proteins which contain them.

Probe design for simultaneous, targeted capture of diverse metagenomic targets.

The compounding challenges of low signal, high background, and uncertain targets plague many metagenomic sequencing efforts. One solution has been DNA capture, wherein probes are designed to hybridize with target sequences, enriching them in relation to their background. However, balancing probe depth with breadth of capture is challenging for diverse targets.