Publications by authors named "Zachary Ye"
Clinical Interpretation of Serum Troponin in the Era of High-Sensitivity Testing.
Diagnostics (Basel)
February 2024
Article Synopsis
- Cardiac troponin (Tn) is crucial for assessing patients with angina and acute coronary syndrome, but while new high-sensitivity tests are more accurate, they can misidentify conditions due to lower specificity.
- Clinical judgment is essential, as doctors must combine various diagnostic tools (like ECGs and exams) to accurately interpret Tn levels and establish a diagnosis.
- Understanding the reasons behind Tn elevation helps differentiate between myocardial ischemia (a specific type of heart issue) and general myocardial injury, which is critical since treatment approaches differ significantly for these conditions.
Several studies have reported on the negative implications of elevated neutrophil-to-lymphocyte ratio (NLR) and elevated platelet-to-lymphocyte ratio (PLR) levels associated with outcomes in many surgical and medical conditions, including cancer. In order to use the inflammatory markers NLR and PLR as prognostic factors in disease, a normal value in disease-free individuals must be identified first. This study aims (1) to establish mean values of various inflammatory markers using a healthy and nationally representative U.
View Article and Find Full Text PDFOur study objectives were to (1) identify the national prevalence and patterns of food insecurity among adults with and without a history of CMCs and (2) determine associations between food insecurity and mental health outcomes among adults with CMCs during the early COVID-19 pandemic period (April−June 2020). We computed prevalence ratios with Poisson regression using the robust estimation of standard errors to identify disparities in the report of food insecurity across demographic groups and by CMC history. Among adults with CMCs, we estimated associations between food insecurity and self-reported mental health symptoms using multinomial logistic regression.
View Article and Find Full Text PDFOur laboratory has developed bioinformatic strategies for identifying distant phylogenetic relationships and characterizing families and superfamilies of transport proteins. Results using these tools suggest that the Anoctamin Superfamily of cation and anion channels, as well as lipid scramblases, includes three functionally characterized families: the Anoctamin (ANO), Transmembrane Channel (TMC) and Ca2+-permeable Stress-gated Cation Channel (CSC) families; as well as four families of functionally uncharacterized proteins, which we refer to as the Anoctamin-like (ANO-L), Transmembrane Channel-like (TMC-L), and CSC-like (CSC-L1 and CSC-L2) families. We have constructed protein clusters and trees showing the relative relationships among the seven families.
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