Publications by authors named "Zachary Vest"
Introduction: This retrospective, consecutive, real-world case series assessed the efficacy and safety of third-generation trabecular micro-bypass stent implantation (iStent infinite) with phacoemulsification in patients with mild-to-moderate primary open-angle glaucoma (POAG).
Methods: Patients underwent phacoemulsification combined with implantation of iStent infinite (containing three stents) by a single U.S.
Purpose: To compare the outcomes of combined cataract surgery with trabecular microbypass stents and ab interno trabeculotomy in patients with open-angle glaucoma.
Setting: University of Toronto, Toronto, Ontario, and University of Montreal, Montreal, Quebec, Canada, and Glaucoma Associates of Texas, Dallas, Texas, USA.
Design: Retrospective case series.
Article Synopsis
- Rift Valley fever virus (RVFV) causes severe disease and abortion in livestock and a range of illnesses in humans, including hemorrhagic fever and hepatitis.
- The virus is primarily transmitted by mosquitoes, but can also spread through contact with infected animal fluids and tissues, highlighting the need for effective treatments and vaccines for humans.
- Studies using golden Syrian hamsters as a model show that RVFV leads to rapid mortality due to fulminant hepatitis, making them suitable for the development of antiviral drugs and vaccines against the virus.
Article Synopsis
- Rift Valley fever virus (RVFV) poses a significant health risk to humans and animals, is transmitted through various means, and currently lacks approved vaccines or treatments.
- The study evaluates DEF201, an adenovirus-vectored interferon alpha, which provides a potential pre- and post-exposure treatment option in a hamster model of RVFV infection.
- Administration of DEF201 intranasally showed complete protection from RVFV even when given shortly before exposure, while post-exposure treatment was effective within 6 hours but not later, indicating its promise as a countermeasure against RVFV.
Article Synopsis
- Rift Valley fever is a serious disease caused by the Rift Valley fever virus (RVFV), which can affect both animals and humans, primarily spread by mosquitoes.
- Currently, there are no approved vaccines or treatments for severe RVFV infections in humans, but research indicates that favipiravir shows promise in combating the virus in laboratory models.
- Tests on hamsters showed that oral favipiravir can significantly prevent death from RVFV when taken shortly after exposure, and combining it with ribavirin improves survival rates and reduces virus levels in the body.
Article Synopsis
- Urtica dioica agglutinin (UDA) is a small lectin that shows potent antiviral effects against SARS-CoV strains, significantly reducing virus replication in cell cultures and in a mouse model.
- In mice treated with UDA, there was a 90% reduction in viral loads and significant protection against weight loss, indicating a therapeutic potential for treating SARS infections.
- UDA seems to work by targeting early stages of the viral replication cycle, specifically inhibiting the virus's ability to bind and penetrate host cells.
Article Synopsis
- - Interferons (IFNs) play a critical role in the immune response to viral infections, and research explores the adenovirus vectored mouse IFN alpha gene (mDEF201) as a potential treatment for SARS-CoV in mice.
- - Mice that received intranasal doses of mDEF201 before exposure to deadly SARS-CoV displayed complete protection and maintained normal body weight post-infection, indicating its effectiveness.
- - The study found that mDEF201 provided protective effects on the lungs in a dose-dependent manner, suggesting it could be a promising new antiviral treatment for SARS-CoV infections.
Clinical and radiographic results after implant removal in idiopathic scoliosis.
Spine (Phila Pa 1976)
September 2007
Study Design: Prospective radiographic and clinical analysis of patients with idiopathic scoliosis who had complete implant removal following posterior spinal fusion (PSF) at least 2 years previously.
Objective: To evaluate the clinical and radiographic effect of implant removal after PSF for idiopathic scoliosis.
Summary Of Background Data: Occasionally, implants must be removed following instrumented PSF.