Publications by authors named "Zachary T Vaneman"
Article Synopsis
- The study investigates how the methyltransferase EZH2 is influenced by both chemical signals like TGF-β1 and mechanical signals from stiff environments, impacting gene expression and potentially advancing cancer and fibrosis.
- Cells cultured on stiff surfaces along with TGF-β1 show increased EZH2 movement to the nucleus and higher levels of a specific histone modification (H3K27me3), which is crucial for regulating gene expression and inducing changes linked to epithelial-mesenchymal transition (EMT).
- The research suggests that the activity of EZH2 relies on cellular contractility pathways involving Rho-associated kinase (ROCK) and myosin II, highlighting a way that stiffness and TGF-β1 work together to
Transforming growth factor (TGF)-β1 is a multifunctional cytokine that plays important roles in health and disease. Previous studies have revealed that TGFβ1 activation, signaling, and downstream cell responses including epithelial-mesenchymal transition (EMT) and apoptosis are regulated by the elasticity or stiffness of the extracellular matrix. However, tissues within the body are not purely elastic, rather they are viscoelastic.
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