Publications by authors named "Zachary Rokop"
Background: Sarcopenia at the time of liver transplantation (LT) is an established risk factor for mortality following LT. However, most studies in this context have defined sarcopenia by one-time, static measurements. The aims of this study were (I) to determine the impact of the rate of muscle loss in waitlisted LT recipients on post-LT outcomes and (II) to identify patterns of serum metabolites associated with patients with more progressive sarcopenia.
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- Liver transplantation is the main treatment for severe liver diseases and certain cancers, but there is limited information on managing tumors that appear after the transplant.
- A study of 54 patients who underwent liver surgery after transplantation found that most had hepatocellular carcinoma (HCC) and many did not receive additional therapies before or after surgery.
- The results indicate that liver resection is generally safe after transplantation, with survival rates comparable to those in patients without a transplant, and should be considered for well-selected patients.
Article Synopsis
- Ischemia-reperfusion injury is a problem that happens in damaged livers during surgeries, and it can be worse in fatty livers.
- Researchers think a process called ferroptosis is a big part of this injury because fatty livers have more fat and stored iron that can cause damage.
- In experiments with mice, those on a high-fat diet showed more liver damage, but treating them with a special drug helped reduce the harm from the injury.
Article Synopsis
- - MNGIE (mitochondrial neurogastrointestinal encephalopathy syndrome) is a rare genetic disorder caused by a deficiency in thymidine phosphorylase, leading to serious issues like gastrointestinal problems, muscle weakness, and neurological symptoms.
- - A case study highlights a 28-year-old man with MNGIE who underwent liver transplantation to improve his symptoms, but still faced ongoing gastrointestinal dysmotility and required nutritional support.
- - After extensive rehabilitation, he received an intestine transplant 2.5 years post-liver transplant, and four years later, he is off nutritional support and gradually improving, marking a significant milestone in treating this condition.
Article Synopsis
- Liver transplantation in infants presents unique challenges, and a study compared split liver transplantation (SLT) and whole liver transplantation (WLT) in this population.
- Researchers analyzed data from 24 infants, finding that SLT had fewer complications and better overall outcomes compared to WLT.
- The study suggests SLT as a preferable option for liver transplants in infants, especially to address donor shortages and improve survival rates.
Article Synopsis
- * In a study involving 173 liver transplant patients, transthoracic echocardiography (TTE) was used to evaluate heart function one day post-surgery, revealing that 82% had hIRI, but there was no significant decline in left ventricular ejection fraction (LVEF) after the transplant.
- * The findings suggest that while hIRI is prevalent, it does not seem to cause an immediate drop in heart function, indicating that other factors may contribute to post-transplant heart issues.
Background: Positive crossmatch (XM+) combined liver-kidney transplantation due to preformed donor-specific human leukocyte antigen antibodies has produced mixed results. We sought to understand the role of delayed kidney transplant approach in XM+ combined liver-kidney transplantations.
Methods: XM+ combined liver-kidney transplantations were retrospectively reviewed.