Synopsis of recent research by authors named "Zachary R Russell"
- Zachary R Russell's recent research focuses primarily on cancer biology, particularly the mechanisms of resistance to targeted therapies in the context of gliomas driven by NTRK gene fusions, as evidenced by his work with genetically engineered mouse models.
- His investigations into RNA Polymerase II hypertranscription reveal its prevalence in human cancers, with implications for poor prognosis, and he has developed innovative methodologies like FFPE-CUTAC for more accurate mapping of transcription activity in formalin-fixed tissues.
- Russell's work also extends to epigenomic studies using formalin-fixed paraffin-embedded samples, overcoming challenges posed by chromatin damage, as well as exploring the interactions in the ectorhizosphere of Setaria to improve agricultural practices in nutrient-poor soils.