Publications by authors named "Zachary Pengju Lin"
Nanoparticles need to navigate a complex microenvironment to target cells in solid tumors after extravasation. Diffusion is currently the accepted primary mechanism for nanoparticle distribution in tumors. However, the extracellular matrix can limit nanoparticle diffusion.
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- - Researchers created a tool called REMNANT for 3D imaging of organic materials, allowing them to visualize liposomes in biological tissues without losing important lipid information during processing.
- - The study showed that liposomes release therapeutic agents over 100 times faster in living tissues compared to traditional lab tests, highlighting the importance of studying drug behavior in realistic conditions.
- - This advancement can lead to improved designs for treatments that target specific cells, like tumor-associated macrophages, and offers new insights for developing better imaging and therapeutic agents in medicine.