Publications by authors named "Zachary Melchiode"
Article Synopsis
- - Chronic kidney disease (CKD) is linked to a higher risk of serious complications after major surgeries, with this study specifically looking at 30-day outcomes across various surgical specialties.
- - Analyzed data from over 1.9 million patients revealed that those with advanced CKD (stage 5) faced significantly greater odds of major complications, including death, unplanned surgeries, and cardiac issues compared to patients with better kidney function (stage 1).
- - The findings emphasize the detrimental effects of CKD on surgical recovery, highlighting the need for careful preoperative assessment in patients with compromised kidney function.
Objective: We sought to examine whether the outcomes of patients who receive a surgical procedure on Friday the 13th differ from patients who receive surgery on flanking Fridays.
Background: Numerous studies have demonstrated that increased anxiety from the provider or patient around the time of surgery can lead to worse outcomes. Superstitious patients often express significant concern and anxiety when undergoing a surgical procedure on Friday the 13th.
Article Synopsis
- The study focuses on first-line treatments for metastatic urothelial carcinoma of the bladder, involving either platinum-based chemotherapy, PD1/L1 inhibitors, or a combination of both; real-world data was used to analyze treatment factors and overall survival.
- Researchers analyzed 4,169 patients diagnosed between 2014 and 2018 using the National Cancer Database, determining that older patients and those with more comorbidities were more likely to receive immunotherapy.
- Findings indicated that combination chemoimmunotherapy improved overall survival compared to chemotherapy alone, especially in patients treated at academic facilities.
Objectives: To evaluate the association between surgical modality (RARC vs. ORC) and the risk of 30-day complications.
Materials And Methods: We utilized the American College of Surgeons-National Surgical Quality Improvement Program (ACS-NSQIP) Cystectomy-Targeted database from 2019 to 2021.
Surgical patients can be discharged to a variety of facilities which vary widely in intensity of care. Postoperative readmissions have been found to be more strongly associated with post-discharge events than pre-discharge complications, indicating the importance of discharge destination. We sought to evaluate the association between discharge destination and 30-day outcomes.
View Article and Find Full Text PDFPhosphodiesterase 5 inhibitors: preclinical and early-phase breakthroughs for impotence treatments.
Expert Opin Investig Drugs
November 2023
Introduction: Erectile dysfunction (ED) is a condition that affects millions of men worldwide and is characterized by the inability to achieve or maintain an erection for satisfactory sexual performance. There are numerous treatment options for ED, including medications, mechanical assist devices, and surgical management; however, first-line treatment is usually a phosphodiesterase 5 (PDE5) inhibitor. There is a growing interest in developing novel, efficacious PDE5 inhibitors that provide better quality, safety, and tolerability profiles with less adverse effects.
View Article and Find Full Text PDFCurrent status of intracavernosal injection therapy in erectile dysfunction.
Expert Opin Pharmacother
June 2023
Introduction: Erectile dysfunction (ED) is defined as the inability to attain and/or maintain a penile erection. The first introduction of intracavernosal injection (ICI) for the treatment of erectile failure was in 1982 by Virag who reported the positive effects of papaverine on erectile tissue, followed by Brindley concurrently conducting research on ICI therapy with alpha-blockade. ICI remains a viable option for the treatment of ED, even after FDA approval of phosphodiesterase type 5 inhibitors in 1998.
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