Resolution analysis of a volumetric coded aperture X-ray diffraction imaging system.

Background: A coded aperture X-ray diffraction (XRD) imaging system can measure the X-ray diffraction form factor from an object in three dimensions -X, Y and Z (depth), broadening the potential application of this technology. However, to optimize XRD systems for specific applications, it is critical to understand how to predict and quantify system performance for each use case.

Objective: The purpose of this work is to present and validate 3D spatial resolution models for XRD imaging systems with a detector-side coded aperture.

Hippocampal Avoidance in Multitarget Radiosurgery.

Brain metastases are a common complication for patients diagnosed with cancer. As stereotactic radiosurgery (SRS) becomes a more prevalent treatment option for patients with many brain metastases, further research is required to better characterize the ability of SRS to treat large numbers of metastases (≥4) and the impact on normal brain tissue and, ultimately, neurocognition and quality of life (QOL). This study serves first as an evaluation of the feasibility of hippocampal avoidance for SRS patients, specifically receiving single-isocenter multitarget treatments (SIMT) planned with volumetric modulated arc therapy (VMAT).

Single isocenter SRS using CAVMAT offers improved robustness to commissioning and treatment delivery uncertainty compared to VMAT.

Purpose: In this study, we evaluate and compare single isocenter multiple target VMAT (SIMT) and Conformal Arc Informed VMAT (CAVMAT) radiosurgery's sensitivity to uncertainties in dosimetric leaf gap (DLG) and treatment delivery. CAVMAT is a novel planning technique that uses multiple target conformal arcs as the starting point for limited inverse VMAT optimization.

Methods: All VMAT and CAVMAT plans were recalculated with DLG values of 0.