Publications by authors named "Zachary Grelewicz"

Purpose: The purpose of this study was to investigate the contemporary distribution of medical physics (MP) employment opportunities across the United States.

Methods And Materials: An annual record (2018-2019) of advertised full-time MP jobs was created using publicly available information from the American Association of Physicists in Medicine and Indeed websites. Listed jobs were categorized based on position name, work experience, job function, and geographic region.

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Purpose: The increased use of image-guided radiation therapy (IGRT) has led to increased use of kV on board imaging (OBI) devices. At present, directly measured OBI beam quality data have only been reported in terms of half-value layers (HVL). However, the HVL metric alone does not give the full OBI energy spectra as needed for accurate beam modeling.

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The purpose of this study was to explore the feasibility of using advanced external beam radiation therapy (EBRT) planning techniques for creating plans that could be used as a possible alternative for high-dose rate (HDR) vaginal cuff brachytherapy (VCBT) boost in treating endometrial cancer. The computed tomography (CT) images of a total of 4 female patients who had endometrial cancer treated with HDR-VCBT were selected for this study. A typical HDR-VCBT target volume, 0.

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Purpose: Most radiation therapy optimization problems can be formulated as an unconstrained problem and solved efficiently by quasi-Newton methods such as the Limited-memory Broyden-Fletcher-Goldfarb-Shanno (L-BFGS) algorithm. However, several next generation planning techniques such as total variation regularization- based optimization and MV+kV optimization, involve constrained or mixed-norm optimization, and cannot be solved by quasi-Newton methods. Using standard optimization algorithms on such problems often leads to prohibitively long optimization times and large memory requirements.

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Article Synopsis
  • The study focuses on developing a new technique to assess the performance of external motion tracking systems in radiotherapy, particularly their ability to detect both translations and rotations in a 6 degree of freedom (6DOF) workspace.
  • The researchers utilized a specially designed robotic motion phantom to achieve highly accurate movements and tested the accuracy of an infrared marker tracking system alongside two 3D optical surface mapping systems.
  • Results showed that the infrared tracking system had lower measurement errors compared to the optical surface tracker, indicating that the infrared system performed better in tracking 6DOF positions during the evaluation.
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Purpose: To develop a control system to correct both translational and rotational head motion deviations in real-time during frameless stereotactic radiosurgery (SRS).

Methods: A novel feedback control with a feed-forward algorithm was utilized to correct for the coupling of translation and rotation present in serial kinematic robotic systems. Input parameters for the algorithm include the real-time 6DOF target position, the frame pitch pivot point to target distance constant, and the translational and angular Linac beam off (gating) tolerance constants for patient safety.

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Purpose: The use of medical technology capable of tracking patient motion or positioning patients along 6 degree-of-freedom (6DOF) has steadily increased in the field of radiation therapy. However, due to the complex nature of tracking and performing 6DOF motion, it is critical that such technology is properly verified to be operating within specifications in order to ensure patient safety. In this study, a robotic motion phantom is presented that can be programmed to perform highly accurate motion along any X (left-right), Y (superior-inferior), Z (anterior-posterior), pitch (around X), roll (around Y), and yaw (around Z) axes.

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Despite the existence of real-time kV intra-fractional tumor tracking strategies for many years, clinical adoption has been held back by concern over the excess kV imaging dose cost to the patient when imaging in continuous fluoroscopic mode. This work aims to solve this problem by investigating, for the first time, the use of convex optimization tools to optimally integrate this excess kV imaging dose into the MV therapeutic dose in order to make real-time kV tracking clinically feasible. Phase space files modeling both a 6 MV treatment beam and a kV on-board-imaging beam of a commercial LINAC were generated with BEAMnrc, and used to generate dose influence matrices in DOSXYZnrc for ten previously treated lung cancer patients.

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Purpose: The spatial and temporal tracking performance of a commercially available 3D optical surface imaging system is evaluated for its potential use in frameless stereotactic radiosurgery head tracking applications.

Methods: Both 3D surface and infrared (IR) marker tracking were performed simultaneously on a head phantom mounted on an xyz motion stage and on four human subjects. To allow spatial and temporal comparison on human subjects, three points were simultaneously monitored, including the upper facial region (3D surface), a dental plate (IR markers), and upper forehead (IR markers).

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Purpose: With the increasing use of external 3D optical tracking cameras to guide modern radiation therapy procedures, it has become vitally important to have an accurate camera to linear accelerator (LINAC) reference frame calibration. To eliminate errors present in current calibration procedures based on the manual hand alignment of a device using the light field crosshairs and in room guidance lasers, a semiautomated quantitative calibration approach requiring only use of an electronic portal imaging device (EPID) was developed.

Methods: A phantom comprised of seven highly IR reflective plastic BBs was placed on the LINAC treatment couch and imaged with both a 3D stereoscopic IR imager and the on board megavoltage (MV) EPID imager.

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