Publications by authors named "Zachary Gallate"

Purpose: To assess the distribution and mechanisms of lower-extremity injuries among high school and college age rugby players presenting to U.S. emergency departments (EDs) from 2008 to 2022.

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Background: Candida auris (C auris) is an emerging global infectious disease threat, and screening practices for identification of C auris are inconsistent across healthcare facilities. This study describes the utility of expanding a C auris admission screening protocol at an acute care hospital to screen all patients presenting from any skilled nursing facility.

Methods: A retrospective review identified all patients screened on admission for C auris from January 2022 through September 2023.

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Background Context: Clinical guidelines, developed in concordance with the literature, are often used to guide surgeons' clinical decision making. Recent advancements of large language models and artificial intelligence (AI) in the medical field come with exciting potential. OpenAI's generative AI model, known as ChatGPT, can quickly synthesize information and generate responses grounded in medical literature, which may prove to be a useful tool in clinical decision-making for spine care.

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Background Context: Venous thromboembolism is a negative outcome of elective spine surgery. However, the use of thromboembolic chemoprophylaxis in this patient population is controversial due to the possible increased risk of epidural hematoma. ChatGPT is an artificial intelligence model which may be able to generate recommendations for thromboembolic prophylaxis in spine surgery.

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Background: Back and neck pain are leading causes of global disability that are associated with intervertebral disc (IVD) degeneration. Causes of IVD degeneration are multifactorial, and diet, age, and diabetes have all been linked to IVD degeneration. Advanced glycation endproducts (AGEs) accumulate in the IVD as a result of aging, diet, and diabetes, and AGE accumulation in the IVD has been shown to induce oxidative stress and catabolic activity that result in collagen damage.

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Article Synopsis
  • Collagen is crucial for the structure of intervertebral disks, with degeneration leading to a shift from collagen type II to type I in the nucleus pulposus, alongside signs of inflammation and fibrosis.
  • A study used second harmonic generation imaging to assess collagen amounts in lumbar intervertebral disks, finding that the intensity of collagen signals increased with degeneration, indicating fibrotic changes in the nucleus pulposus.
  • The analysis showed reduced complexity and uniformity in the annulus fibrosus collagen structure with degeneration, highlighting a transition towards a more fibrotic and less organized state in the disks.
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