Publications by authors named "Zachary G Vest"
Article Synopsis
- Urtica dioica agglutinin (UDA) is a small lectin that shows potent antiviral effects against SARS-CoV strains, significantly reducing virus replication in cell cultures and in a mouse model.
- In mice treated with UDA, there was a 90% reduction in viral loads and significant protection against weight loss, indicating a therapeutic potential for treating SARS infections.
- UDA seems to work by targeting early stages of the viral replication cycle, specifically inhibiting the virus's ability to bind and penetrate host cells.
Antiviral Res
January 2011
Article Synopsis
- - Interferons (IFNs) play a critical role in the immune response to viral infections, and research explores the adenovirus vectored mouse IFN alpha gene (mDEF201) as a potential treatment for SARS-CoV in mice.
- - Mice that received intranasal doses of mDEF201 before exposure to deadly SARS-CoV displayed complete protection and maintained normal body weight post-infection, indicating its effectiveness.
- - The study found that mDEF201 provided protective effects on the lungs in a dose-dependent manner, suggesting it could be a promising new antiviral treatment for SARS-CoV infections.
