Publications by authors named "Zachary B Bjornson-Hooper"
Article Synopsis
- The study investigates the biological factors that influence the severity of COVID-19 by analyzing over 1,400 plasma proteins and various immune cell features in patients with different levels of illness.
- Researchers evaluated data from 97 COVID-19 patients and 40 uninfected individuals using computational methods, leading to the development of a model that accurately classifies COVID-19 severity.
- The findings highlight key immune signaling pathways that are disrupted during COVID-19 and identify potential therapeutic targets for managing the disease's progression.
Assessing the health and competence of the immune system is central to evaluating vaccination responses, autoimmune conditions, cancer prognosis, and treatment. With an increasing number of studies examining immune dysregulation, there is a growing need for a curated reference of variation in immune parameters in healthy individuals. We used mass cytometry (CyTOF) to profile blood from 86 humans in response to 15 immune stimuli.
View Article and Find Full Text PDFAnimal models are an integral part of the drug development and evaluation process. However, they are unsurprisingly imperfect reflections of humans, and the extent and nature of many immunological differences are unknown. With the rise of targeted and biological therapeutics, it is increasingly important that we understand the molecular differences in the immunological behavior of humans and model organisms.
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