Publications by authors named "Zachary A Yahiku"
Article Synopsis
- Transmembrane protein 184B (TMEM184B) plays a crucial role in brain development and is linked to neurodevelopmental disorders when mutated.
- Six pediatric patients with neurodevelopmental issues, such as intellectual disability and microcephaly, were found to have rare genetic variants in TMEM184B affecting protein stability and function.
- Experimental studies in zebrafish and cell lines showed that these mutations lead to similar symptoms observed in patients, indicating that TMEM184B variants disrupt cellular processes and contribute to abnormal neural development.
