Gata3 is required in late proneurosensory development for proper sensory cell formation and organization.

It has previously been shown that the zinc-finger transcription factor Gata3 has dynamic expression within the inner ear throughout embryonic development and is essential for cochlear neurosensory development. However, the temporal window for which Gata3 is required for proper formation of the cochlear neurosensory epithelia remains unclear. To investigate the role of Gata3 in cochlear neurosensory development in the late prosensory stages, we used the Sox2-cre mouse line to target and conditionally delete Gata3 at E11.

Gata3 is Required in Late Proneurosensory Development for Proper Sensory Cell Formation and Organization.

It has been previously shown that zinc-finger transcription factor has dynamic expression within the inner ear throughout embryonic development and is essential for cochlear neurosensory development. However, the temporal window to which is required for the formation of the cochlear neurosensory epithelia remains unclear. To investigate the role of on cochlear neurosensory development in the late prosensory stages, we used the mouse line to target and conditionally delete at E11.

Expression Within Inner Ear Afferent Neurons Is Necessary for Central Pathfinding.

During development the afferent neurons of the inner ear make precise wiring decisions in the hindbrain reflective of their topographic distribution in the periphery. This is critical for the formation of sensory maps capable of faithfully processing both auditory and vestibular input. Disorganized central projections of inner ear afferents in null mice indicate Wnt/PCP signaling is involved in this process and ear transplantation in indicates that is necessary in the ear but not the hindbrain for proper afferent navigation.