Publications by authors named "Zachary A Osman"
Background: Large language models (LLMs) that can efficiently screen and identify studies meeting specific criteria would streamline literature reviews. Additionally, those capable of extracting data from publications would enhance knowledge discovery by reducing the burden on human reviewers.
Methods: We created an automated pipeline utilizing OpenAI GPT-4 32 K API version "2023-05-15" to evaluate the accuracy of the LLM GPT-4 responses to queries about published papers on HIV drug resistance (HIVDR) with and without an instruction sheet.
Article Synopsis
- A new HIV-1 capsid inhibitor, lenacapavir, necessitates the sequencing of capsid proteins in patients who have experienced this treatment to monitor viral presence.
- The study analyzed capsid sequences from over 21,000 HIV-1 individuals to assess amino acid variation, focusing on how these variations relate to virus subtype and immune system pressure.
- Results show that a majority of capsid positions have either no or only minor mutations, and understanding these variations is crucial for effective sequence interpretation and identifying potential new mutations linked to lenacapavir treatment.