Farnesoid X nuclear receptor agonists for the treatment of nonalcoholic steatohepatitis.

Nonalcoholic fatty liver disease (NAFLD) affects 20-40% of the general population. Despite significant disease burden and mortality associated with advanced disease, i.e.

Obese Children with Metabolic Syndrome Have 3 Times Higher Risk to Have Nonalcoholic Fatty Liver Disease Compared with Those without Metabolic Syndrome.

Background: The aim of this study was to investigate the relationship between metabolic syndrome (MS) and nonalcoholic fatty liver disease (NAFLD) in obese children. One hundred and twenty-five subjects aged 11-12 years old participated in the study.

Methods: Anthropometric and biochemical indices were measured, including lipid and liver profile, blood glucose, serum insulin, and liver ultrasound.

Multifocal Epithelioid Hemangioendothelioma of the Foot and Ankle Developing a Postoperative Infection-Long-term Outcome: A Case Report.

A case of rare epithelioid hemangioendothelioma with multiple foot and ankle lytic lesions in a 41-year-old male is reported. The patient presented to our hospital after having received treatment elsewhere and developing a local postoperative infection. After thorough investigations and establishing the diagnosis, we initially treated the local infection and highlighted the potential risk of malignancy.

Associations of Apolipoprotein A, High-Sensitivity C-Reactive Protein and Fasting Plasma Insulin in Obese Children With and Without Family History of Cardiovascular Disease.

Background: The worldwide prevalence of childhood obesity has increased from 4.2% to 6.7% during the last two decades.

Clitoromegaly as first presentation of a neurocutaneous syndrome in a 3-year-old girl.

A rare cause of clitoral hypertrophy in a child is neurofibromatosis type 1 (NF1). Although evaluation, including karyotype and hormonal studies, is necessary to exclude ambiguous genitalia, the diagnosis of neurofibromatosis as a possible cause of clitoromegaly may help avoid lengthy and sometimes invasive interventions.

Multifocal epithelioid hemangioendothelioma of the foot and ankle: a case report.

We report on a 41-year-old man with multiple epithelioid hemangioendothelioma of the left foot and ankle. The patient was treated with curettage and fixation with 2 separate plates, but later developed local infection. Owing to the potential for malignancy, below-knee amputation was suggested, but the patient declined and was treated symptomatically with close monitoring.

Possible Health Implications and Low Vitamin D Status during Childhood and Adolescence: An Updated Mini Review.

Vitamin D deficiency is common in the developing countries and exists in both childhood and adult life. The great importance of Vitamin D is the moderation of calcium (Ca) and phosphorus (P) homeostasis as well as the absorption of Ca. While insufficiency of vitamin D is a significant contributing factor to risk of rickets in childhood, it is possible that a more marginal deficiency of vitamin D during life span contribute to osteoporosis as well as potentially to the development and various other chronic diseases such as cardiovascular disease, cancer and diabetes.

Peripheral neuropathy is an early complication of type 2 diabetes in adolescence.

Objective: To screen for microvascular complications in adolescents with type 2 diabetes mellitus (T2DM).

Subjects And Methods: Seven adolescents with T2DM were assessed for early secondary complications. Median duration of diabetes was 1.

Discitis in toddlers: a case series and review.

Unlabelled: Toddlers commonly present to medical services with non-specific symptoms. The presence of refusal to walk and nocturnal waking with crying should alert clinicians to the possibility of discitis.

Conclusion: Features that may alert clinicians to the diagnosis of discitis in young children are reviewed.

Animal and human bites: evaluation and management.

Animal bites and to a lesser extent human bites are common trauma cases in accident and emergency units and their incidence is rising. Bite wounds are often deeper than they appear to be and they are potentially contaminated with uncommon microorganisms. They need careful assessment, thorough debridement and preferably delayed primary closure.