Publications by authors named "Zachariah W Foster"
Repetitive head impacts (RHI) and traumatic brain injuries are risk factors for the neurodegenerative diseases chronic traumatic encephalopathy (CTE) and amyotrophic lateral sclerosis (ALS). ALS and CTE are distinct disorders, yet in some instances, share pathology, affect similar brain regions, and occur together. The pathways involved and biomarkers for diagnosis of both diseases are largely unknown.
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- The study investigates how the ALS functional rating scale-revised (ALSFRS-R) correlates with the underlying neuropathology in military veterans with ALS.
- Using hierarchical cluster analysis, three distinct groups of motor dysfunction were identified based on ALSFRS-R subdomain scores, each showing different relationships with neuropathological variables.
- Findings suggest that variations in motor dysfunction profiles correspond to specific types of ALS-related brain damage, highlighting the potential of ALSFRS-R subdomain scores in understanding disease progression and clinical variability in ALS research.
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting both the upper and lower motor neurons. Although ALS typically leads to death within 3 to 5 years after initial symptom onset, approximately 10% of patients with ALS live more than 10 years after symptom onset. We set out to determine similarities and differences in clinical presentation and neuropathology in persons with ALS with long vs.
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