Publications by authors named "Zachariah J Piper"
After spinal cord injury, there is an extensive infiltration of immune cells, which exacerbates the injury and leads to further neural degeneration. Therefore, a major aim of current research involves targeting the immune response as a treatment for spinal cord injury. Although much research has been performed analyzing the complex inflammatory process following spinal cord injury, there remain major discrepancies within previous literature regarding the timeline of local cytokine regulation.
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- Traumatic spinal cord injury (SCI) leads to significant loss of motor and sensory functions, with current treatments failing to ensure meaningful recovery.
- The injury causes immediate damage and initiates a harmful cascade involving ischemia and inflammation that can last over six months.
- This review assesses immune responses and cytokine actions in rodent models, underscoring the need to better understand the underlying mechanisms of secondary injury to develop effective therapeutic strategies.