infection promotes TNF-α signaling and SMAC mimetic-mediated apoptosis in human prostate cancer.

Growing evidence suggests an association between Mycoplasma infections and the development and progression of prostate cancer (PCa). In this study, we report that chronic and persistent infection induced robust TNF-α secretion from PCa cells. TNF-α secreted from -infected PCa cells subsequently led to activation of the NF-κB pathway.