Publications by authors named "Zach Chamberlain"
is a Gram-negative facultative intracellular bacterial pathogen that is classified by the Centers for Disease Control and Prevention as a Tier 1 Select Agent. infection causes the disease tularemia, also known as rabbit fever. Treatment of tularemia is limited to few effective antibiotics which are associated with high relapse rates, toxicity, and potential emergence of antibiotic-resistant strains.
View Article and Find Full Text PDFArticle Synopsis
- Phagocytic cells can ingest bacteria from infected cells without killing the original host cell, as shown in earlier research (Steele et al., 2016).
- This study investigates what happens immediately after the bacteria are transferred, finding that they are contained within double-membrane vesicles that contain components from the original infected cell’s plasma membrane.
- The researchers used a specific strain of bacteria to observe that this transfer occurs in the lungs of infected mice, supporting the idea that macrophages can acquire material from other cells through a unique process related to phagocytosis.