Adaptive responses of TRPC1 and TRPC3 during skeletal muscle atrophy and regrowth.

Introduction: We assessed the time-dependent changes of transient receptor potential canonical type 1 (TRPC1) and TRPC3 expression and localization associated with muscle atrophy and regrowth in vivo.

Methods: Mice were subjected to hindlimb unloading for 7 or 14 days (7U, 14U) followed by 3, 7, or 14 days of reloading (3R, 7R, 14R).

Results: Soleus muscle mass and tetanic force were reduced significantly at 7U and 14U and recovered by 14R.