Publications by authors named "Zabn Allah M Alaizeri"

Nanocomposites (NCs) have attractive potential applications in gas-sensing, energy, photocatalysis, and biomedicine. In the present work, the fabrication of CuO/ZrO/TiO/RGO nanocomposites (NCs) was done a simple chemical route. Our aim in this work was to synthesis and investigate the selective anticancer activity of TiO NPs by supporting CuO, ZrO, and RGO toward cancer and normal cells.

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The present work was designed to synthesize AgO-supported MgO/rGO nanocomposites (NCs) via green method using Phoenix leaf extract for improved photocatalytic and anticancer activity. Green synthesized AgO-supported MgO/rGO NCs were characterized through X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), X-ray photoelectron spectroscopy (XPS), Raman, ultraviolet-visible (UV-vis) spectroscopy, and photoluminescence (PL) spectroscopy, and gas chromatography-mass spectroscopy (GC-MS) was applied to examine the chemical components of the Phoenix leaf extract. Characterization data confirmed the preparation of MgO NPs, AgO-MgO NCs, and AgO-MgO/rGO NC with particle size of 26-28 nm.

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The purpose of the present study is to enhance the anticancer and biocompatibility performance of TiO NPs, ZnO NPs, ZnO-TiO (NCs), and ZnO-TiO/reduced graphene oxide (RGO) NCs against two types of human cancer (HCT116) and normal (HUVCE) cells. A novel procedure for synthesizing ZnO-TiO/RGO NCs has been developed using extract. The improved physicochemical properties of the obtained samples were investigated using different techniques such as XRD, TEM, SEM, XPS, FTIR, DLS and UV-visible spectroscopy.

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Zinc ferrite nanoparticles (ZnFeO NPs) have attracted extensive attention for their diverse applications including sensing, waste-water treatment, and biomedicine. The novelty of the present work is the fabrication of ZnFeO/RGO NCs by using a one-step hydrothermal process to assess the influence of RGO doping on the physicochemical properties and anticancer efficacy of ZnFeO NPs. X-ray diffraction (XRD), Scanning electron microscopy (SEM), Energy-dispersive X-ray(EDX), X-ray photoelectron spectroscopy (XPS), Fourier-transform infrared spectroscopy (FTIR), UV-vis spectroscopy, and Photoluminescence (PL) spectroscopy were employed to characterize prepared pure ZnFeO NPs and ZnFeO/ RGO NCs.

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Graphene derivatives and metal oxide-based nanocomposites (NCs) are being studied for their diverse applications including gas sensing, environmental remediation, and biomedicine. The aim of the present work was to evaluate the effect of rGO and BiO integration on photocatalytic and anticancer efficacy. A novel BiO-WO/rGO NCs was successfully prepared via the precipitation method.

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Article Synopsis
  • A series of novel 1,2,3-triazole and 1,2,3-triazoline glycosides were synthesized from d-arabinose to create hybrid molecules featuring sugar azide, with key steps involving the protection of hydroxyl groups and introduction of ethylene glycol.
  • The synthesis of azido ethyl-O-β-d-arabinofuranoside was achieved using sodium azide to replace a tosylate group, followed by a 1,3-dipolar cycloaddition reaction with various alkenes and alkynes to create new glycosides.
  • Characterization through various analytical techniques confirmed moderate to high antimicrobial activity against test microorganisms, alongside promising pharmacokinetic properties, with molecular docking analysis
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The incorporation of graphene with metal oxide has been widely explored in various fields, including energy storage devices, optical applications, biomedical applications, and water remediation. This research aimed to assess the impact of reduced graphene oxide (RGO) doping on the photocatalytic and anticancer properties of InO nanoparticles. Pure and InO/RGO nanocomposites were effectively synthesized using the single-step microwave hydrothermal process.

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We report a simple method to prepare colloidal trimetallic (Ni-Cu)@Ag core@shell nanoparticles (NPs) without stabilizing materials. Experimental evidence was found for the successful synthesis of these NPs using X-ray diffraction (XRD), optical spectroscopy, and high-resolution transmission electron microscopy (HRTEM). The presence of core metals (Ni and Cu) was confirmed by elemental analysis using a total reflection X-ray fluorescence (TXRF) analysis.

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Indium oxide nanoparticles (InO NPs) are being investigated for a number of applications including gas-sensing, environmental remediation, and biomedicine. We aimed to examine the effect of silver (Ag) doping on photocatalytic and anticancer activity of InO NPs. The Ag-doped (2%, 4%, and 6%weight) InO NPs were synthesized by the photodeposition method.

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In this work, the carbon monoxide (CO) detection property of poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate)/poly(-anisidine) (PEDOT:PSS/PPA) nanocomposite was systematically investigated at room temperature. The PEDOT:PSS/PPA nanocomposite was synthesized by the cost-effective "in situ chemical oxidation polymerization" technique. The electric, optical, spectroscopic, and structural properties of the as-prepared nanomaterials were analyzed with -, UV-vis, Raman, Fourier transform infrared (FTIR), and X-ray diffraction (XRD) spectroscopies.

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Article Synopsis
  • A new series of mono-5-isoxazolidines and bis (5-isoxazolidines) was synthesized through a specific chemical reaction aimed at developing new antimicrobial and antioxidant drugs.
  • The compounds were fully characterized using advanced techniques like FT-IR and NMR spectroscopy, and their physicochemical and pharmacokinetic properties were predicted using computational methods.
  • Many of the synthesized compounds demonstrated significant antimicrobial and antifungal activity, outperforming standard drugs in some cases, with varying levels of antioxidant properties revealed through further testing and molecular docking studies.
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Metal oxide and graphene derivative-based nanocomposites (NCs) are attractive to the fields of environmental remediation, optics, and cancer therapy owing to their remarkable physicochemical characteristics. There is limited information on the environmental and biomedical applications of tin oxide-reduced graphene oxide nanocomposites (SnO-rGO NCs). The goal of this work was to explore the photocatalytic activity and anticancer efficacy of SnO-rGO NCs.

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Due to unique physicochemical properties, magnesium oxide nanoparticles (MgO NPs) have shown great potential for various applications, including biomedical and environmental remediation. Moreover, the physiochemical properties of MgO NPs can be tailored by metal ion doping that can be utilized in photocatalytic performance and in the biomedical field. There is limited study on the photocatalytic activity and biocompatibility of silver (Ag)-doped MgO NPs.

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Bismuth (III) oxide nanoparticles (BiO NPs) have shown great potential for biomedical applications because of their tunable physicochemical properties. In this work, pure and Zn-doped (1 and 3 mol %) BiO NPs were synthesized by a facile chemical route and their cytotoxicity was examined in cancer cells and normal cells. The X-ray diffraction results show that the tetragonal phase of β-BiO remains unchanged after Zn-doping.

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This study aimed to generate a comparative data on biological response of yttrium oxide nanoparticles (YO NPs) with the antioxidant CeO NPs and pro-oxidant ZnO NPs. Sizes of YO NPs were found to be in the range of 35±10 nm as measured by TEM and were larger from its hydrodynamic sizes in water (1004 ± 134 nm), PBS (3373 ± 249 nm), serum free culture media (1735 ± 305 nm) and complete culture media (542 ± 108 nm). Surface reactivity of YO NPs with bovine serum albumin (BSA) was found significantly higher than for CeO and ZnO NPs.

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Widespread application of titanium dioxide nanoparticles (nTiO) and ubiquitous cadmium (Cd) pollution may increase their chance of co-existence in the natural environment. Toxicological information on co-exposure of nTiO and Cd in mammalian models is largely lacking. Hence, we studied the combined effects of nTiO and Cd in human liver (HepG2) and breast cancer (MCF-7) cells.

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Graphene-based nanocomposites have attracted enormous interest in nanomedicine and environmental remediation, owing to their unique characteristics. The increased production and widespread application of these nanocomposites might raise concern about their adverse health effects. In this study, for the first time, we examine the cytotoxicity and oxidative stress response of a relatively new nanocomposite of cerium oxide-reduced graphene oxide (CeO-RGO) in human lung epithelial (A549) cells.

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