Spiroconjugated 1,2,3-triazolo[5,1-]1,3,4-thiadiazine stimulates functional activity of fibroblasts under skin injury regeneration.

Background And Purpose: One of the most important mechanisms of tissue regeneration is the high functional activity of cells, including proliferation. Currently, there are practically no effective skin cell activators on the pharmaceutical market. The purpose of this work was to demonstrate the stimulating effect of spiroconjugated 1,2,3-triazolo[5,1-]1,3,4-thiadiazine (STT) on the functional activity of fibroblasts.

[Use of meglumine sodium succinate and NPWT therapy in the treatment of early and late complications of cholelistics].

Gallstone disease remains an important medical and socially significant problem due to the increase in the proportion of patients of young and working age. At the same time, along with the increase in incidence, the number of complicated forms, such as choledocholithiasis in combination with stenosing duodenal papillitis (SDP) and obstructive jaundice, is increasing, which increases the importance of surgical approaches in the complex treatment of the disease and expands the range of conservative methods of therapy. In the given clinical observation of a young patient with severe cholelithiasis, accompanied by early and late complications, including the formation of postoperative scars and ventral hernias.

[Caroli disease: optimizing the choice of surgical strategy using 3D modeling, 3D printing and therapy].

A patient with Caroli disease is described. The authors used 3D modeling and 3D printing when choosing surgical strategy. Advisability of 1.

[Cardiohemodynamic Changes and Cardiac Arrhythmias After Coronavirus Infection].

Aim      To study changes in cardiohemodynamic alterations of the myocardium and heart rhythm disorders at 3 and 6 months following the coronavirus infection.Material and methods   EchoCG, ECG Holter monitoring, and Doppler ultrasonography of hepatolienal blood vessels were performed for 77 patients (mean age, 35.9 years) at 3 and 6 months after coronavirus infection.

[3D-modelling and 3D-printing in diagnosis and treatment of common bile duct stricture].

An example of the use of 3D-modeling of 3D-printing in the diagnosis and choice of a surgical approach for the treatment of hepaticocholedochal stricture is given. The inclusion of meglumine sodium succinate (intravenous drip, once a day, 500 ml, course of 10 days) into the therapy regimen was substantiated, which contributed to the reduction of intoxication syndrome due to its antihypoxic mechanism of action and, as a result, to a reduction in the duration of hospitalization and an increase in the quality of life of the patient.

[Complicated visceral artery aneurysms in chronic pancreatitis].

Visceral artery aneurysms are rare and occur only in 0.01-0.2% of people.

Levitation conditions for condensing droplets over heated liquid surfaces.

We report experimental studies and develop mathematical models of levitation of microscale droplets over an evaporating liquid layer. The maximum size of droplets is estimated from the balance between gravity and Stokes force due to the action of upward Stefan flow generated by evaporation. Mathematical models of diffusion around levitating droplets allow us to determine Stefan flow velocity at the liquid layer surface.

Frequency Response Stabilization and Comparative Studies of MET Hydrophone at Marine Seismic Exploration Systems.

Low frequency hydrophone with a frequency range of 1-300 Hz for marine seismic exploration systems has been developed. The operation principle of the hydrophone bases on the molecular electronic transfer that allows high sensitivity and low level self-noise at low frequencies (<10 Hz) to be achieved. The paper presents a stabilization method of the frequency response within the frequency range at a depth up to 30 m.

Study of Transfer Characteristics of a Molecular Electronic Sensor for Borehole Surveys at High Temperatures and Pressures.

The paper considers the development and experimental study of the characteristics of a high-temperature motion parameter sensor based on molecular-electronic technology (MET) operating at elevated pressures. Studies were conducted in an extended temperature range (25-125 °C) with a static external pressure of up to 10 atm. A pilot plant based on a high-pressure chamber with the ability to output an electrical signal was specially designed and commissioned.

Levitation and Self-Organization of Liquid Microdroplets over Dry Heated Substrates.

Levitating droplets of liquid condensate are known to organize themselves into ordered arrays over hot liquid-gas interfaces. We report experimental observation of similar behavior over a dry heated solid surface. Even though the lifetime of the array is shorter in this case, its geometric characteristics are remarkably similar to the case of droplets levitating over liquid-gas interfaces.

[Expression of plant antimicrobial peptide pro-SmAMP2 gene increases resistance of transgenic potato plants to Alternaria and Fusarium pathogens].

The chickweed (Stellaria media L.) pro-SmAMP2 gene encodes the hevein-like peptides that have in vitro antimicrobial activity against certain harmful microorganisms. These peptides play an important role in protecting the chickweed plants from infection, and the pro-SmAMP2 gene was previously used to protect transgenic tobacco and Arabidopsis plants from phytopathogens.

[Possibilities of liquid biopsy in gastric cancer].

The increasing popularity of the concept of liquid biopsy, which involves the definition of circulating tumor cells and circulating nucleic acids in the blood can significantly improve long-term results of treatment for gastric cancer due to the high sensitivity of techniques. It needs further study in relation to gastric cancer, the search for universal markers and methods.

Molecular Electronic Angular Motion Transducer Broad Band Self-Noise.

Modern molecular electronic transfer (MET) angular motion sensors combine high technical characteristics with low cost. Self-noise is one of the key characteristics which determine applications for MET sensors. However, until the present there has not been a model describing the sensor noise in the complete operating frequency range.

Diffusive Propagation of Exciton-Polaritons through Thin Crystal Slabs.

If light beam propagates through matter containing point impurity centers, the amount of energy absorbed by the media is expected to be either independent of the impurity concentration N or proportional to N, corresponding to the intrinsic absorption or impurity absorption, respectively. Comparative studies of the resonant transmission of light in the vicinity of exciton resonances measured for 15 few-micron GaAs crystal slabs with different values of N, reveal a surprising tendency. While N spans almost five decimal orders of magnitude, the normalized spectrally-integrated absorption of light scales with the impurity concentration as N(1/6).

[Photogenerator of trichloroacetic acid--a perspective detritylation agent for microchip oligonucleotide synthesis].

For the purpose of new detritylation agents search for microarray oligonucleotide synthesis we investigated applicability of [4-(4-methoxyphenyl)-2,6-dinitro-phenyl](phenyl)methyl 2,2,2-trichloroacetate for 4,4'-dimethoxytrityl group detritylation during oligonucleotide syntheses generating trichloroacetic acid at radiation by light with a length of wave of 405 nanometers. [4-(4-Methoxyphenyl)-2,6-dinitro-phenyl](phenyl)methyl 2,2,2-trichloroacetate has been successfully used for solid-phase oligonucleotide synthesis of desired oligonucleotides.

[Effects of local induction of ipt-gene in roots on cytokinins content in leaf cells tobacco plants].

Identification of cytokinins in differentiated leaf cells has received little attention. We have carried out immunohistochemical localization of cytokinins in leaves of transgenic tobacco plants in which the level of increased due to induced in their roots the expression of ipt-gene controlling cytokinin synthesis. Immuno-labeling of cytokinins with the help of antibodies raised against zeatin riboside was characteristic of mesophyll cells.

[Endovideosurgical interventions for thoracoabdominal wounds].

The authors presented results of examination and treatment of 1347 patients with different injuries of the chest and abdomen. Medico-diagnostic measures used in treatment of such kind of patients with rational application of endovideosurgical techniques such as thoraco- and laparoscopy are described which proved to be the final kind of operative treatment.

[Diaphragmatic hernias. Diagnosis and surgical treatment].

The authors present results of the examination and treatment of 106 patients with hernias of the diaphragm of different genesis. In 79 of them there were non-incarcerated hernias, in 27--there were incarcerated hernias. The authors suggest necessary medico-diagnostic measures with rational application of endovideosurgical technologies such as thoraco- and laproscopy which were used in 74%.

[Thoracoscopy in verification and treatment of pleural exudate syndrome under conditions of a multifield hospital].

Under an analysis of results of treatment of 186 patients with pleural exudate syndrome there were 139 patients treated by traditional methods, 47 patients treated using the proposed medico-diagnostic program based on using thoracosopy under local anesthesia. Using the proposed medico-diagnostic measures can be used at any multifield hospital where patients with pleural exudate syndrome are admitted although the hospital has neither phthisiatrical nor phthisiothoracic departments.

[Thoracoscopy in the diagnostics and treatment of chest injury].

The authors have analyzed their experience with treatment of 67 casualties with injuries of the chest of different character. The diagnostic and treatment algorithm was based on the principle of using primary thoracoscopy with local anesthesia during draining the pleural cavity. The proposed algorithm can be used at any hospital rendering emergency to casualties with injuries of the chest independent of the level of available equipment.

[Vegetative disturbances and dysfunction of the endothelium in patients with postinfarction cardiosclerosis].

We assessed vegetative status and parameters of endothelial function in 53 patients with postinfarction cardiosclerosis. Balance of autonomic nervous system was characterized by the Kerdo index and heart rate variability at Holter monitoring, endothelial function - by quantity of desquamated endotheliocytes in blood and vasomotor function in test with reactive hyperemia. Patients with higher class of angina and sympatheticotonia had pronounced disturbance of endothelial function appearing as increase in number of circulating desquamated endotheliocytes and diminished sensitivity of brachial artery endothelium to shear stress.

Numerical simulation of local heat transfer in rotating two-pass square channels.

3D turbulent air flow and heat transfer developing in a two-pass square channel rotating in the orthogonal mode are simulated using the high-Re k-epsilon turbulence model and a recently developed modification of wall functions. Auxiliary problem for accurate definition of inlet boundary conditions formed by a long unheated upstream section is considered. Details of flow structure are presented.