Interaction of population density and slope will exacerbate spatiotemporal changes in land use and landscape patterns in mountain city.

The complex topography of the mountain cities leads to uneven distribution of land resources. Currently, available studies mainly focuse on land use and landscape patterns (LU and LP) in plains or plateaus. Thus, it is necessary to carry out an analysis of the drivers of changes in LU and LP in mountain cities.

Assessment of Peripheral Neuropathy Using Current Perception Threshold Measurement in Patients with Spinocerebellar Ataxia Type 3.

Peripheral neuropathy (PN) identified as a significant contributor to disability in Spinocerebellar ataxia type 3 (SCA3) patients. This study seeks to assess the utility of current perception threshold (CPT) measurements in evaluating PN in individuals with SCA3 and aims to identify factors influencing CPT values in SCA3 and ascertain whether these values correlate with the severity of ataxia. Ninety-four patients diagnosed with SCA3 and 44 healthy controls were recruited for this investigation.

Carbon-carbon triple bond cleavage and reconstitution to achieve aryl amidation using nitrous acid esters.

C-C bond cleavage and recombination provide an efficient strategy for the modification and reconstruction of molecule structures. Herein, we present a method for achieving amidation of aryl C(sp)-H bond through the cleavage and recombination of C-C triple bond with the involvement of nitrous acid esters. This method marks the instance of precise and controlled stepwise cleavage of C-C triple bond, offering a fresh perspective for the cleavage of such bonds.

A Fish-Gill-Inspired Biomimetic Multiscale-Ordered Hydrogel-Based Solar Water Evaporator for Highly Efficient Salt-Rejecting Seawater Desalination.

Solar energy-driven steam generation is a renewable, energy-efficient technology that can alleviate the global clean water shortage through seawater desalination. However, the contradiction between resistance to salinity accretion and maintaining high water evaporation properties remains a challenging bottleneck. Herein, we have developed a biomimetic multiscale-ordered hydrogel-based solar water evaporator for efficient seawater desalination.

An Evaluation on Five Dimensions of a Mobile Health Application for Patient Counseling in Ambulatory Care Pharmacy: A Single-center Cross-sectional Survey Based on Pediatric Caregiver's Opinion.

Objective: Due to high workloads and insufficient counseling time in ambulatory care pharmacy, outpatient pharmacists for pediatric patients in China proposed a mobile health application (mHealth app) that they considered could provide patient counseling more efficiently. To improve it accordingly, we need to design a more specific and multi-dimensional evaluation method to obtain pediatric caregivers' evaluations of a mHealth app.

Methods: A cross-sectional survey on five dimensions (transmission, accuracy, accessibility, completeness, and experience) of the mHealth app was conducted using a random questionnaire among outpatient caregivers at a children's hospital.

Atomically precise silver-based bimetallic clusters for electrocatalytic urea synthesis.

Electrocatalytic urea synthesis from CO and nitrate holds immense promise as a sustainable strategy, but its complicated synthesis steps and controversial C-N coupling mechanism restrict the design of efficient catalysts. Atomically precise metal cluster materials are ideal model catalysts for investigating the C-N coupling issues. Here we synthesize two atomically precise bimetallic clusters, AgPd(PTFE)(TPP) and AgAu(PTFE)(DPPP), both with icosahedral cores and similar ligands.

Protective Effect of Rosmarinic Acid on Endotoxin-Induced Neuronal Damage Through Modulating GRP78/PERK/MANF Pathway.

Objective: Neuronal damage is criminal to cognitive dysfunction, closely related to endoplasmic reticulum stress (ERS). However, due to the pathogenesis of endotoxin-induced long-term cognitive dysfunction is not fully clarified, there is still a lack of effective treatment. This study was conducted to explore the protective effects and mechanism of rosmarinic acid (RA) against ERS in endotoxin-induced cognitive dysfunction in mice and neuronal injury in cells.

Nonreciprocal magnon laser in a spinning cavity optomagnonic system.

We introduce a novel, to the best of our knowledge, method to achieve a highly efficient nonreciprocal magnon laser within a spinning cavity optomagnonic system, which integrates a magnon mode and two optical modes. The rotation of the YIG sphere triggers the Barnett effect in the magnon mode and the Sagnac effect in the optical modes. The directional input of a pump light leads to opposite Sagnac-Fizeau frequency shifts in these modes.

Two dimensional confinement induced discontinuous chain transitions for augmented electrocaloric cooling.

Overheating remains a major barrier to chip miniaturization, leading to device malfunction. Addressing the urgent need for thermal management promotes the development of solid-state electrocaloric cooling. However, enhancing passive heat dissipation through two-dimensional materials in electrocaloric polymers typically compromises the electrocaloric effect.

The prognostic value of systemic immune-inflammation index in patients with unresectable hepatocellular carcinoma treated with immune-based therapy.

Background: Predicting the efficacy of immune-based therapy in patients with unresectable hepatocellular carcinoma (HCC) remains a clinical challenge. This study aims to evaluate the prognostic value of the systemic immune-inflammation index (SII) in forecasting treatment response and survival outcomes for HCC patients undergoing immune-based therapy.

Methods: We analyzed a cohort of 268 HCC patients treated with immune-based therapy from January 2019 to March 2023.

A metal-organic framework with mixed electron donor and electron acceptor ligands for efficient lithium-ion storage.

Electron donor tetrathiafulvalene (TTF) and electron acceptor naphthalene diimide (NDI) derivatives were used to synthesize a 3D Zn-TTF/NDI-MOF. Multiple redox active sites and charge transfer endow the pristine MOF anode with excellent rate behavior and long term cycling performance (with an average specific capacity of 956 mA h g at 1 A g over 600 cycles). This study highlights the great potential of elaborately-designed MOFs for developing efficient anode materials.

TDCPP promotes apoptosis and inhibits the calcium signaling pathway in human neural stem cells.

Tris (1, 3-dichloro-2-propyl) phosphate (TDCPP) is an extensively used organophosphorus flame retardant (OFR). Previous studies have suggested that it has neurotoxic effects, but the neurotoxicity mechanism is still unclear. Neural stem cells are an important in vitro model for studying the neurotoxicity mechanism of pollutants.

The Construction of a Stream Service Application with DeepStream and Simple Realtime Server Using Containerization for Edge Computing.

This paper addresses the increasing demand for efficient and scalable streaming service applications within the context of edge computing, utilizing NVIDIA Jetson Xavier NX hardware and Docker. The study evaluates the performance of DeepStream and Simple Realtime Server, demonstrating that containerized applications can achieve performance levels comparable to traditional physical machines. The results indicate that WebRTC provides superior low-latency capabilities, achieving delays of around 5 s, while HLS typically experiences delays exceeding 10 s.

Synthesis of Oxazoles Containing CF-Substituted Alcohol Unit via Tandem Cycloisomerization/Hydroxyalkylation from -Propargylamides with Trifluoropyruvates.

Oxazoles are important five-membered heterocycles that contain both nitrogen and oxygen atoms. Due to their wide range of biological activities, many oxazoles demonstrate potential for extensive application in various fields, including medicinal chemistry. Trifluoromethyl carbinol, an important pharmacophore, contains both trifluoromethyl and hydroxyl groups and is common in molecules with important biological activities.

Rapid and accurate multi-phenotype imputation for millions of individuals.

Deep phenotyping can enhance the power of genetic analysis, including genome-wide association studies (GWAS), but the occurrence of missing phenotypes compromises the potential of such resources. Although many phenotypic imputation methods have been developed, the accurate imputation of millions of individuals remains challenging. In the present study, we have developed a multi-phenotype imputation method based on mixed fast random forest (PIXANT) by leveraging efficient machine learning (ML)-based algorithms.

R(3780) Resonance Interpreted as the 1^{3}D_{1}-Wave Dominant State of Charmonium from Precise Measurements of the Cross Section of e^{+}e^{-}→Hadrons.

We report the precise measurements of the cross section of e^{+}e^{-}→hadrons at center-of-mass energies from 3.645 to 3.871 GeV.

First Report of Charcoal Rot Caused by of Sweet Potato in Southern China.

Sweet potato ( (L.) Lam) is a major food crop that is cultivated in southern China (Huang et al. 2020).

Medicago2035: Genomes, Functional Genomics and Molecular Breeding.

Medicago, a member of the Leguminosae or Fabaceae family, encompasses the most significant forage crops globally, notably alfalfa (Medicago sativa L.). Its close diploid relative, Medicago truncatula, serves as an exemplary model plant for investigating leguminous growth and development, as well as its symbiosis with rhizobia.

Epilepsy and brain health: a large prospective cohort study.

Background: Epilepsy, as a chronic noncommunicable disease with recurrent seizures, may be a marker of deterioration or alteration in other underlying neurological diseases. This study aimed to investigate the relationship of epilepsy with brain function, other common brain disorders, and their underlying mechanisms.

Methods: The study was based on clinical diagnostic and test data from 426,527 participants in the UK Biobank, of whom 3,251 were diagnosed with epilepsy at baseline.

TaqMan-based quantitative real-time polymerase chain reaction assay to detect porcine circovirus-like virus.

The aim of this study was to develop a rapid, sensitive and highly specific TaqMan quantitative real-time polymerase chain reaction PCR (qPCR) assay for porcine circovirus-like virus (PCLV). The primers and probe were designed based on the conserved regions of the PCLV ORF4 gene. The assay has a good detection performance (y=-3.

Dimensional early life adversity and anxiety symptoms: A network analysis and longitudinal study.

Background: Accumulating literature has found a close relation between early life adversity (ELA) and anxiety. However, previous studies did not rule out the high co-occurrence of different types of ELA when exploring the association of ELA and anxiety. In the present study, we carried out network analysis based on a cross-sectional sample and longitudinal sample to investigate the relationship between ELA and anxiety symptoms in non-clinical populations over time.