Publications by authors named "ZORIN A"

Article Synopsis
  • Carbasugars are carbohydrate derivatives where the ring oxygen is replaced by a methylene group, resulting in a molecule that resembles traditional sugars but behaves differently.
  • These compounds, including unsaturated cyclohexenols and various sugars, are found in both bacteria and humans, serving as important neurotransmitters like inositol trisphosphate.
  • The article reviews various synthesis methods for carbasugars and their derivatives, highlighting their significance in research areas such as enzyme inhibition, lectin-binding, and potential treatments for HIV and cancer.
View Article and Find Full Text PDF

Aim: To study demographic and clinical characteristics and to give a comparative description of the functional and hemodynamic status, profile of concomitant pathology in patients with various forms of pulmonary arterial hypertension (PAH), and chronic thromboembolic pulmonary hypertension (CTEPH) according to the Russian National Registry.

Methods: During the period from January 01, 2012, till January 01, 2019, 1105 patients aged >18 years with verified diagnosis of PAH and CTEPH, who were subsequently observed at 15 PH expert centers of the Russian Federation in the 52 provinces, are included in the Russian registry on the basis of the Federal State Budgetary Institution of Cardiology of the Ministry of Healthcare of Russia. All newly diagnosed patients ( = 727) were entered into the registry database (NCT03707561).

View Article and Find Full Text PDF

The amount of omics data in the public domain is increasing every year. Modern science has become a data-intensive discipline. Innovative solutions for data management, data sharing, and for discovering novel datasets are therefore increasingly required.

View Article and Find Full Text PDF

The number of bariatric (weight loss) surgeries have increased steadily in the past decade. Along with the tangible benefit of this treatment, there is a risk for postoperative complications, the main cause of which is impaired absorption of nutrients. The paper describes polyradiculoneuropathy running as a type of Guillain-Barré syndrome.

View Article and Find Full Text PDF

Aim: To examine the antihypertensive effect of the synthetic analogue of the endogenous nitric oxide donors in patients with grades 2-3 hypertension and uncomplicated hypertensive crisis (HC).

Subjects And Methods: The study included 30 male patients aged 35 to 73 years (mean age 55.5 ± 10.

View Article and Find Full Text PDF

Using an optimally coupled nanometer-scale SQUID, we measure the magnetic flux originating from an individual ferromagnetic Ni nanotube attached to a Si cantilever. At the same time, we detect the nanotube's volume magnetization using torque magnetometry. We observe both the predicted reversible and irreversible reversal processes.

View Article and Find Full Text PDF

We propose a transistorlike circuit including two serially connected segments of a narrow superconducting nanowire joint by a wider segment with a capacitively coupled gate in between. This circuit is made of amorphous NbSi film and embedded in a network of on-chip Cr microresistors ensuring a sufficiently high external electromagnetic impedance. Assuming a virtual regime of quantum phase slips (QPS) in two narrow segments of the wire, leading to quantum interference of voltages on these segments, this circuit is dual to the dc SQUID.

View Article and Find Full Text PDF

A comparative study of hypotensive effects of binuclear forms of dinitrosyl iron complexes (DNICs) with glutathione, S-nitrosoglutathione (GS-NO) and sodium nitrite (NaNO(2)) on rats has been carried out. The latter appeared to be the least efficient, viz., mean arterial pressure (MAP) decreased by 10 and 30 mmHg at 25 and 100 μmoles/kg of NaNO(2).

View Article and Find Full Text PDF

On the basis of earlier executed studies of hypotensive effect of dinitrosyl iron complexes (DNIC) with glutathione, the drug has been created in industrial conditions named oxacom. Preliminary pharmacological studies of oxacom have not revealed negative qualities. The drug has been now tested in 14 healthy men in whom at single intravenous introduction it caused typical response - a decrease of diastolic as well as systolic arterial pressure on 24-27 mmHg through 3-4 min with subsequent very slow restoration in 8-10 hours.

View Article and Find Full Text PDF

We investigate a quadratic-quartic anharmonic oscillator formed by a potential well between two potential barriers. We realize this novel potential with a dc SQUID at near-zero current bias and flux bias near half a flux quantum. Escape out of the central well can occur via tunneling through either of the two barriers.

View Article and Find Full Text PDF

Aim: To study morphological features and functional activity of platelets, their relations with the level of inflammation markers in coronary heart disease (CHD) patients with depression.

Material And Methods: The study group consisted of 33 CHD patients with stable effort angina (NY-HA FC I-III), 14 had depression, 19 were free of depression. Sixteen healthy volunteers comprised the control group.

View Article and Find Full Text PDF

This paper presents a biologically motivated model of breast cancer development and detection allowing for arbitrary screening schedules and the effects of clinical covariates recorded at the time of diagnosis on posttreatment survival. Biologically meaningful parameters of the model are estimated by the method of maximum likelihood from the data on age and tumor size at detection that resulted from two randomized trials known as the Canadian National Breast Screening Studies. When properly calibrated, the model provides a good description of the U.

View Article and Find Full Text PDF

Latent dysfunction of the heart right ventricle and hypovolemia were assessed in 50 patients divided into 4 groups, operated on the heart, abdominal aorta and lungs. It was found that after revascularization of the myocardium the diastolic disorders prevailed. In patients operated for the heart valve (mitral and aortal) diseases prevailing were the systolic and pump dysfunction of the right ventricle.

View Article and Find Full Text PDF

We show that the electrical impedance of a small-capacitance Josephson junction also includes, in addition to the capacitive term -i/(omega)CB, an inductive term i(omega)LB. Similar to the known Bloch capacitance CB(q), the Bloch inductance LB(q) also depends periodically on the quasicharge, q, and its maximum value achieved at q=e(mod 2e) always exceeds the value of the Josephson inductance of this junction LJ(phi) at fixed phi=0. The effect of the Bloch inductance on the dynamics of a single junction and a one-dimensional array is described.

View Article and Find Full Text PDF

We observed current-voltage characteristics of superconducting single charge transistors with on-chip resistors of R approximately R(Q)=h/4e(2) approximately 6.45 kOmega, which are explained in terms of Cooper pair cotunneling. Both the effective strength of Josephson coupling and the cotunneling current are modulated by the gate-induced charge on the transistor island.

View Article and Find Full Text PDF

According to our previous model, oligodendrocyte--type 2 (O-2A) astrocyte progenitor cells become competent for differentiation in vitro after they complete a certain number of critical mitotic cycles. After attaining the competency to differentiate, progenitor cells divide with fixed probability p in subsequent cycles. The number of critical cycles is random; analysis of data suggests that it varies from zero to two.

View Article and Find Full Text PDF

A recent theoretical result of Kendal (1998) enabled us to develop a survival model which allows for proliferation of tumor clonogenic cells in the course of fractionated radiotherapy. We explored this model during an analysis of clinical data on survival of 982 patients with cancer of the cervix uteri. The model provided a good description of survival patterns in different groups of patients.

View Article and Find Full Text PDF

This paper is concerned with modern approaches to mechanistic modeling of the process of cancer detection. Measurements of tumor size at diagnosis represent a valuable source of information to enrich statistical inference on the processes underlying tumor latency. One possible way of utilizing this information is to model cancer detection as a quantal response variable.

View Article and Find Full Text PDF

A quantum electrometer is proposed which is based on charge modulation of the Josephson supercurrent in the Bloch transistor inserted in a superconducting ring. As this ring is inductively coupled to a high- Q resonance tank circuit, the variations of the charge on the transistor island are converted into variations of amplitude and phase of oscillations in the tank. These variations are amplified and then detected.

View Article and Find Full Text PDF