[Dynamics of indicators of blood coagulation and fibrinolysis in patients with diffuse peritonitis].

Blood coagulation and fibrinolysis were studied in 34 patients with diffuse peritonitis treated in intensive care wards of common profile. Forced ventilation of the lungs was carried out for 2-26 days in 32 of 34 patients. The causes of peritonitis were perforating gastroduodenal ulcers (22 cases), acute perforating ulcers of the small intestine (5 cases), and acute phlegmonous perforative cholecystitis (7 cases).

[Stages of disseminated intravascular coagulation after resuscitation in patients with massive hemorrhage and severe multiple trauma].

Changes in blood coagulation and fibrinolysis were followed up in 255 patients of intensive care wards during 5 days after effective treatment of grave and terminal stages of traumatic hemorrhagic shock. Four stages in the development of disseminated intravascular coagulation (DIC) were distinguished. Special attention is paid to the time course of the third stage with repeated hypercoagulation, suppressed fibrinolysis, and microthrombolysis in organs and tissues leading to multiple organ failure.

[The pathogenetic and treatment problems of multiple organ failure in patients with severe combined trauma and massive blood loss in the early postresuscitation period].

Analysis of the results of treatment of 583 patients with grave and terminal stages of shock resultant from severe combined injuries and blood loss, hospitalized in resuscitation wards, showed visceral involvement and development of pyoinflammatory complications in the early postresuscitation period (days 5-10 of treatment) in 43.6% cases. Prolonged mixed type hypoxia and persistence of impaired tissue perfusion, shown by rheovasography, play an important role in the mechanisms of development of complications.

[Significance of tissue perfusion disorders and disseminated intravascular blood coagulation in the pathogenesis of post-resuscitation disease in patients with massive hemorrhage and severe multiple trauma].

A total of 198 patients with massive blood loss and grave combined injury treated at the intensive care ward were monitored for 5 days. This paper presents data on the blood content of peripheral tissues assessed by rheovasography and the time course of coagulating characteristics of the blood and fibrinolysis. Despite the stabilization of arterial pressure in the first hours of treatment, disorders of tissue perfusion persisted for 5 days.

[Aspects of pathogenesis of "shock lung" in patients with massive blood loss and trauma in the early postresuscitation period].

116 patients with massive blood loss and trauma have been studied in intensive care units. It has been established that the main reason for the onset of hypoxemia in "shock lung" is disturbed gas exchange in the lungs due to an expanded physiological dead space (VD/VT) and blood shunting in the lungs (QS/QT). Intravascular blood coagulation is one of the main reasons for the development and maintenance of systemic hypoperfusion in the lung tissue.

[Metabolic alkalosis in patients following resuscitation].

Among 3425 patients treated in the general reanimation department metabolic alkalosis was observed in 445 patients (13%). More than a half of these patients (241) showed marked hemodynamic disturbances on admission (massive blood loss, multiple grave traumas or major operations). The phenomena of hypovolemia and disturbances in peripheral circulation with recommendations on their correction are described.