[The anti-arrhythmia activity of isoteolin (IST)].

The antiarrhythmic activity of IST was studied on some experimental models of cardiac arrhythmia--caused by adrenaline in rats, caused by barium in non-narcotized rabbits, caused by strophanthin in guinea pigs, caused by aconitine and calcium in rats. Rhythmic disturbances were recorded by a 12-channel polyphysiograph "Galileo" or a single-channel electrocardiograph "Cardiomat". The obtained results showed that IST manifested antiarrhythmic activity in respect to adrenaline, barium and strophanthin arrhythmias without affecting substantially aconitine and calcium arrhythmias.

[A neuropharmacological study of isoteolin (IST)].

Neuropharmacological study of IST was carried out on mice and rats, using the so-called practically "blind" neuropharmacological screening of M. Nikolova and L. Daleva (1968).

[The effects of isotheoline (IST) on the nonvascular smooth musculature].

The influence of IZT on nonvascular smooth musculature in experiments in vitro was studied: on isolated intestine of the rabbit, ileum of the guinea pig, an uterine horn of the rat and guinea pig, vas deferens of the rat; as well as in vivo: on an experimental model of bronchospasm of guinea pigs, induced by acetylcholine, histamine and serotonin. Isometric contractions were recorded, and in the experiments in vivo--the tonus of the bronchial smooth musculature by a piston recorder. The obtained results showed that in experiments in vitro IZT increased the dose dependent tonus of intestinal smooth musculature; inhibited predominantly at low concentrations like clonidine the contractions of vas deferens of the rat by low frequent field stimulation--0.

[The effects of compound IZ35 on the beta-adrenergic mediator system].

The biological activity of the compound Iz35, representing rigid conformer of triquinol in respect to the cardiovascular system and smooth musculature, was studied. The arterial blood pressure and heart frequency were recorded in cats and rabbits as well as the tonus of smooth musculature of bronchial tree, uterus and intestines in experiments in vivo and in vitro of rats, guinea pigs and rabbits. It was established that the compound Iz35, administered in a wide range of doses of 0.

[Antiexudative effect of naringin in experimental pulmonary edema and peritonitis].

The authors examined antiexudative activity of bioflavonoids naringin and rutin in comparative aspect in two models of acute inflammation. The experiments were carried out on 180 male white rats and 24 guinea pigs. The two flavonoids manifested marked antiexudative effect in rats with experiments peritonitis, induced by the model of U.

[Gentamicin toxicity to animals of both sexes and different ages].

Gentamycin acute toxicity in sexually-immature and sexually-mature male and female rats was tested comparatively. DL50 for the female sexually-mature rats was found to be statistically reliable lower than that for the remaining three groups of animals. The greatest differences were observed in the values for the maximum non-lethal and minimum lethal doses of this antibiotic.