Decision-Making for Ablation of Colorectal Liver Oligometastases Patients: A 10-Year Retrospective Study of Survival Outcomes Based on Right-Versus Left-Sided Primary Tumor Location.

ObjectiveTo develop a prognostic model for optimizing management of colorectal liver oligometastases (CLOM) patients with different primary tumor locations who underwent thermal ablation (TA).Materials and MethodsThe reporting of this retrospective study conforms to STROBE guidelines. A total of 525 CLOM patients who underwent TA from 3 hospitals between 2011 and 2021 were enrolled.

YBX1-driven TUBB6 upregulation facilitates ocular angiogenesis via WNT3A-FZD8 pathway.

Pathological ocular neovascularization, a characteristic feature of proliferative ocular diseases, is a primary contributor to global vision impairment. The dynamics of tubulin are crucial in maintaining ocular homeostasis, closely linked to cellular proliferation and angiogenesis. Elucidating the molecular mechanisms driving this process is vital for formulating effective therapeutic strategies.

Vinyl polymers with fully degradable carbon backbones enabled by aromatization-driven C-C bond cleavage.

Degradation of carbon-backbone polymers, which make up most plastics, remains a formidable challenge owing to strong and inert main-chain C-C bonds. While incorporation of comonomers that generate backbone radicals under certain conditions can induce degradation of the polymer chain, such strategies yield complex oligomer mixtures. Here we report aromatization-driven C-C bond cleavage as a viable and powerful strategy to endow the degradability into carbon backbones using acrylic polymers as a model example.

Therapeutic potential of Da Cheng Qi Decoction and its ingredients in regulating ferroptosis via the NOX2-GPX4 signaling pathway to alleviate and predict severe acute pancreatitis.

Objective: This study aimed to elucidate the protective effects of Da Cheng Qi Decoction (DCQD) on severe acute pancreatitis (SAP) by targeting ferroptosis in pancreatic acinar cells and to establish a predictive signature and nomogram for acute pancreatitis (AP) risk assessment.

Methods: We utilized microarray analysis to delineate gene expression patterns among 32 healthy controls and 87 AP patients stratified by severity. Employing SAP models and NOX2-deficient cells, we investigated the molecular underpinnings of ferroptosis.

Atroposelective Synthesis of Pyridoindolones Bearing Two Remote Distinct C-N Axes through Cobalt-Catalyzed Enantioselective C-H Activation.

C-N axially chiral compounds represent an important class of atropisomers that are prevalent in bioactive and material molecules. Despite recent advances in synthetic methodologies, the asymmetric construction of atropisomers featuring multiple C-N axes has been rarely explored, significantly limiting their further applications. Herein, we report a novel atroposelective synthesis of diaxially chiral pyridoindolones featuring both six-five and six-six C-N axes through cobalt-catalyzed asymmetric C-H annulation.

IL6-Dependent PIEZO1 Activation Promotes M1-Mediated Orthodontic Root Resorption via CXCL12/CXCR4.

Orthodontic root resorption (ORR) is a common yet significant complication of orthodontic treatment, largely driven by interactions between periodontal ligament cells (PDLCs) and M1 macrophages. Despite the clinical relevance of ORR, the role of mechanosensitive ion channels in PDLC-mediated ORR and the underlying mechanisms regulating inflammatory cell recruitment remain poorly understood. Here, we identified PIEZO1 as a critical mechanosensitive ion channel that modulates monocyte recruitment and ORR.

Three-dimensional location approach with silk thread guided hepatectomy for liver tumor.

Background: Intraoperative determination of resection margin and adequate residual liver parenchyma are the key points of hepatectomy for the treatment of liver tumors. Intraoperative ultrasound and indocyanine green fluorescence navigation are the most commonly used methods at present, but the technical barriers limit their promotion.

Aim: To evaluate the value of the three-dimensional location approach with silk thread (3D-LAST) in precise resection of liver tumors.

The molecular mechanism of ginsenoside Rh2 and its octyl ester derivative on anti-angiogenesis in cancer treatment: The battle between PI3K and ROS.

Background: The cancer treatments that target tumor associated angiogenesis (TAA) induced by vascular endothelial growth factor A (VEGFA) have become valued. Ginsenoside Rh2 has been proved to inhibit TAA through VEGFA. However, the underlying mechanisms remain unclear.

Anatomic versus nonanatomic resection for intrahepatic cholangiocarcinoma: a systematic review and meta-analysis.

Background: The value of anatomic resection (AR) in intrahepatic cholangiocarcinoma (ICC) remains controversial. This study compares the perioperative safety and long-term outcomes of AR versus nonanatomic resection (NAR) in ICC patients.

Methods: A systematic search was conducted in PubMed, Medline, Embase, Cochrane Library, China National Knowledge Infrastructure(CNKI), and Wanfang database for prospective or retrospective studies comparing the efficacy of AR and NAR in, ICC published to 1 June 2024.

Intraluminal brachytherapy using I seed strand combined with PTBD and Hepatic arterial infusion chemotherapy for unresectable Bismuth-Corlette III and IV stage hilar cholangiocarcinoma.

Purpose: To evaluate the safety and efficacy of I seed strand combined with percutaneous transhepatic biliary drainage (PTBD) and hepatic arterial infusion chemotherapy (HAIC) for unresectable Bismuth-Corlette III and IV stage hilar cholangiocarcinoma (HCCA).

Methods: From January 2018 to December 2021, a total of 128 Bismuth-Corlette III and IV stage HCCA patients with obstructive jaundice were included in this single-center retrospective study. Forty-eight patients underwent I seed strand combined with PTBD and HAIC (group A).

Effect of ultrasound-guided acupotomy combined with acupuncture on limb dysfunction in patients with cerebral stroke.

Objective: This study aimed to determine the repeatable effect of acupotomy on specific acupoints of paralyzed limbs in stroke patients with hemiplegia, using musculoskeletal ultrasound combined with acupuncture.

Methods: 102 patients with limb motor dysfunction post-cerebral stroke were randomly divided into two groups: the treatment group (T group) received ultrasound-guided acupotomy plus a basic treatment regimen (51 patients) and the control (C) group underwent the basic treatment regimen (51 patients) over 4 weeks, with a 6-month follow-up period. The T group was treated with ultrasound-guided acupotomy on the first day.

[Disseminated intravascular coagulation caused by exertional heat stroke: a case report and literature review].

To explore the mechanisms and clinical manifestations of disseminated intravascular coagulation (DIC) caused by exertional heat stroke. Analyze the clinical data of a patient with exertional heat stroke in Yichang Central People's Hospital and review relevant literature to evaluate the association between heat stroke and DIC, summarizing clinical presentations and laboratory findings. The patient exhibited symptoms such as high fever and altered consciousness after engaging in intense labor in a high-temperature environment.

Medroxyprogesterone promotes neuronal survival after cerebral ischemic stroke by inhibiting PARthanatos.

Introduction: Cerebral ischemic stroke (CIS) is caused by the interruption of cerebral blood circulation due to thrombosis or embolism and is the second-leading cause of mortality worldwide. The neuronal death and motor dysfunction resulting from CIS are primarily attributed to the induction of PARthanatos in neurons at the site of ischemia. Blocking parthanatos is a promising treatment for CIS.

[Advances in the study of polyetheretherketone and its composites in the field of dental implantology].

Polyetheretherketone (PEEK) and its composite materials have garnered widespread attention in the field of dental implantology due to their good biocompatibility, mechanical properties, and corrosion resistance. The low elastic modulus of PEEK, comparable to that of human jawbone, helps to reduce the stress shielding effect around the implant, thereby enhancing the rate of bone integration. This article reviews the latest research progress of PEEK and its composite materials in the field of dental implantation, including the synthesis of materials, surface modification techniques, and applications in implant-abutment-crown complexes and full-arch denture bridges.

Mitochondrial ROS-associated integrated stress response is involved in arsenic-induced blood-testis barrier disruption and protective effect of melatonin.

Arsenic (As) is an environmental metalloid. Previous studies have demonstrated that As exposure resulted in decline of sperm quality. This study aimed to investigate the impact of exposure to As on blood-testis barrier (BTB) in a mouse model.

Functional exploration of the Sex combs reduced gene in Gryllus bimaculatus.

The Hox gene Sex combs reduced (Scr) is recognized as a key factor in the development of the head and thorax in insects. However, its function in the growth, development and morphogenesis of Gryllus bimaculatus remains poorly understood. This study aimed to explore the function of the Scr gene in G.

Gate-Opening Effect in a Flexible Metal-Organic Framework for Sieving Acetylene.

Adsorptive separation employing porous materials is one of the most promising alternative technologies for CH purification due to its energy-efficient and environmentally friendly advantages. Herein, we present the design and synthesis of a dicopper-paddle-wheel-based metal-organic framework (termed JNU-5-Me) with a carboxylate-azolate organic linker. The use of such a linker results in the axial positions of the dicopper paddle wheels being occupied by azolates, and therefore, a much-improved chemical stability of the framework structure.

Human urine stem cells protect against cyclophosphamide-induced premature ovarian failure by inhibiting SLC1A4-mediated outflux of intracellular serine in ovarian granulosa cells.

Background: Cyclophosphamide (CTX) is the first-line medication for the treatment of breast cancer, although it potentially leads to severe ovarian dysfunction and even premature ovarian failure (POF). However, the mechanism of CTX-induced POF remains unclear. Mesenchymal stem cell-based therapy has been wildly used for treating numerous diseases.

[Prevalence of common chronic diseases and related factors in HIV-infected persons in Henan Province, 2023].

To understand the prevalence and related factors of three common chronic diseases, hyperlipidemia, hypertension and diabetes in HIV-infected persons. As of December 2023, HIV-infected persons >15 years old who are receiving antiviral therapy (ART) and follow-up in Henan Province were selected as the study objects. Questionnaires, physical examinations, and blood samples were collected to collect demographic information, ART, body weight, blood lipids, blood pressure, and blood sugar of HIV-infected persons.

The Role of Ion Channels in Pulmonary Hypertension: A Review.

Pulmonary hypertension (PH) constitutes a critical challenge in cardiopulmonary medicine with a pathogenesis that is multifaceted and intricate. Ion channels, crucial determinants of cellular electrochemical gradient modulation, have emerged as significant participants in the pathophysiological progression of PH. These channels, abundant on the membranes of pulmonary artery smooth muscle cells (PASMCs) and pulmonary artery endothelial cells (PAECs), pivotally navigate the nuanced interplay of cell proliferation, migration, and endothelial function, each vital to the pulmonary vascular remodeling (PVR) hallmark of PH.

Enhancing hole injection efficiency in an AlGaN-based deep ultraviolet laser diode by three-terminal structure with the AlScN ferroelectric layer.

Here, we have designed a novel, to the best of our knowledge, three-terminal AlGaN-based deep-ultraviolet (DUV) laser diode (LD), featuring an AlScN ferroelectric layer beneath the third terminal and a stepped ridge structure. Our findings indicate that when the AlScN layer is negatively polarized by an external bias by the third terminal, the fixed polarization positive charges at the AlScN/p-GaN interface can enhance hole injection efficiency by modulating the energy band in the p-type region near the AlScN layer. The modulation does not deteriorate the electron injection and the optical field confinement, thus effectively increasing the stimulated recombination rate in the active region.

Two-Dimensional Nanostructured TiCT MXene for Ceramic Materials: Preparation and Applications.

TiCT MXene, a novel two-dimensional transition metal carbide with nanoscale dimensions, has attracted significant attention due to its exceptional structural and performance characteristics. This review comprehensively examines various preparation methods for TiCT MXene, including acid etching, acid-salt composite etching, alkali etching, and molten salt etching. It further discusses several strategies for interlayer exfoliation, highlighting the advantages and limitations of each method.

Radial growth responses of var. with different stand ages and diameter classes to drought events.

We explored the differences in the impacts of drought events on var. of different ages (30 and 40 years) and different diameter classes (large 20-24.9 cm, medium 15-19.

Harnessing the power of ginger leaf polysaccharide: A potential strategy to combat Aβ-induced toxicity through the Wnt/β-catenin pathway.

Alzheimer's disease (AD) is prevalent in the elderly, with amyloid-β (Aβ) playing a critical role in its progression. Polysaccharides have garnered increasing attention due to their low toxicity and diverse applications in alleviating AD-like symptoms. However, the potential of ginger leaf polysaccharide in mitigating AD-like symptoms has been rarely investigated.