Publications by authors named "ZALEWSKI J"
Background: The role of a prothrombotic state in atrial fibrillation (AF) progression to permanent arrythmia (PerAF) is unclear. Formation of denser and poorly lysable fibrin clots has been observed in AF patients also with sinus rhythm in association with higher stroke risk. We investigated whether altered fibrin clot properties and other prothrombotic state markers may contribute to AF transition to PerAF.
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- The study aimed to investigate how high-dose statins impact the formation of neutrophil extracellular traps (NETs) in patients with coronary artery disease (CAD).
- A group of 130 patients was monitored before and after starting statin therapy, revealing significant reductions in proteins linked to NETs, such as citrullinated histone H3, myeloperoxidase, and neutrophil elastase.
- These reductions correlated with decreased inflammation markers and changes that suggest improved clot formation properties, indicating that statins may have beneficial effects beyond just lowering LDL cholesterol.
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- Postthrombotic syndrome (PTS) is a common inflammatory complication that arises after deep vein thrombosis (DVT), and this study investigates the role of elevated factor XI (FXI) in the occurrence of PTS.
- Researchers measured FXI levels and several inflammatory and clot-related markers in 180 patients with first-time DVT, finding a significant association between higher FXI levels and the severity of PTS symptoms as measured by the Villalta score.
- The study concludes that increased FXI, linked to inflammation and clot properties, may play a crucial role in the development of PTS, with implications for both PTS occurrence and the recurrence of venous thromboembolism (VTE).
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- - This study examines the relationship between plasma protein carbonyls (PC), which indicate oxidative stress, and the risk of ischemic stroke in atrial fibrillation (AF) patients on anticoagulation therapy.
- - Researchers analyzed data from 243 AF patients over a median follow-up of 53 months, finding that higher baseline PC levels were significantly associated with increased stroke risk, even after accounting for other factors.
- - The results suggest that elevated protein carbonylation in AF patients may contribute to a higher "residual" stroke risk, possibly due to changes in fibrin clot characteristics despite being on anticoagulant medication.
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- * CCI is rare, with a reported incidence of 0.009% among stroke patients, leading to very high mortality rates, yet there are no established guidelines for its diagnosis or treatment.
- * This review discusses the current understanding of diagnosing and treating CCIs, including case studies to illustrate different scenarios, and expresses hope for improved management practices through future clinical research.
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- - The study aimed to characterize Polish patients with heart failure with improved ejection fraction (HFimpEF) and assess their long-term mortality, finding that 17.9% of patients with initial reduced ejection fraction improved to HFimpEF.
- - HFimpEF patients were more likely to be female and had better baseline heart function, with lower occurrences of diabetes and severe chronic kidney disease compared to those who did not improve (HFnon-impEF).
- - Over a median follow-up of about 49 months, HFimpEF patients showed a significantly lower annual mortality rate (10.8%) compared to HFnon-impEF patients (16.4%), indicating better long-term survival in those with improved ejection fraction
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- Takotsubo syndrome (TTS) can lead to coronary slow flow (CSF) during acute myocardial infarction, but its long-term implications are not well understood.
- Among 7,771 MI patients studied, CSF was present in 40.2% of TTS patients, showing a significant difference in heart function and triggers compared to those with normal flow.
- CSF was linked to a higher all-cause mortality rate over a median follow-up of 55 months, marking it as an important predictor of poor long-term outcomes in TTS patients.
This study aimed to assess the influence of ischemic preconditioning (IP) on hypoxia/reoxygenation (HR)-induced endothelial cell (EC) death. Human umbilical vein endothelial cells (HUVECs) were subjected to 2 or 6 h hypoxia with subsequent reoxygenation. IP was induced by 20 min of hypoxia followed by 20 min of reoxygenation.
View Article and Find Full Text PDFStatins exert antithrombotic effects, which might contribute to reduced risk of venous thromboembolism (VTE). Rosuvastatin 20 mg/d administered for 4 weeks has been reported to decrease coagulation factors (F) VII, FVIII, and FXI in VTE patients. Moreover, in accordance with recent registry data in non-VTE subjects, statins usage was associated with lower FXI.
View Article and Find Full Text PDFBackground: Residual pulmonary vascular obstruction (RPVO) is common following pulmonary embolism (PE) but its association with fibrin clot properties is poorly understood. We investigated whether prothrombotic state and hypofibrinolysis markers can identify patients with RPVO.
Methods: In 79 normotensive noncancer patients (aged 56 ± 13.
Rat bite fever (RBF) is a rare infectious zoonotic disease caused by two bacterial species: the Gram-negative rod Streptobacillus moniliformis and the Gram-negative coiled rod Spirillum minus. The association between RBF and skin vasculitis and arthritis has been observed. The aim of this paper was to present a case of rat-bite fever with symptoms of skin vasculitis and arthritis, associated with high titers of ANCA antibodies and anti-endothelial cell antibodies suggestive of primary vasculitis.
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- High-dose statin therapy, specifically rosuvastatin and atorvastatin, was studied to assess its effects on coagulation factors and fibrin clot properties in patients with coronary artery disease (CAD).
- The research involved 130 CAD patients, who underwent evaluations before and after treatment, revealing a significant reduction in LDL cholesterol and specific coagulation factors (FVII, FVIII, FXI) after statin therapy.
- The findings suggest that the reduction of FXI may lead to a less prothrombotic fibrin clot structure, highlighting the additional antithrombotic benefits of high-dose statins.
Background: Periprosthetic femoral fractures (PFFs) in total hip arthroplasty (THA), especially those in contact with the diaphyseal stem, carry high morbidity. This study evaluated how stem design influences the risk of early Vancouver B PFF or other PFF requiring operative intervention after THA.
Methods: A multicenter, retrospective study of 3,433 primary cementless THAs performed from 2014 to 2021 included 2,302 single-taper (micro M/L [n = 1,169]; M/L [n = 1,133]) and 1,131 double-taper (fit-and-fill [n = 420]; compaction-collared [n = 711]) stems.
Background: The phrase "dysfunctional high-density lipoprotein" has been developed in the literature to describe the particle which loses its basic role- anti-oxidative and anti-inflammatory activity. In this porcess, the significance of enzymes- pro-oxidant myeloperoxidase (MPO) and antioxidant paraoxonase-1 (PON-1) from the perspective of HDL-C function has been noted.
Aims: The objective of this study was to analyze the associations between two enzymes -MPO and PON-1 and type 2 diabetes (T2DM) in patients with ischemic heart disease (IHD).
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- Arginase inhibition in an animal model of myocardial infarction results in increased plasma citrulline and a higher citrulline/ornithine (C/O) ratio, while decreasing plasma ornithine and the ornithine/arginine (O/A) ratio.
- In a study of 100 myocardial infarction patients, those with thin-cap fibroatheroma (TCFA) lesions had a significantly lower C/O ratio and alterations in intima-media thickness were correlated with changes in arginine metabolites at 6 months post-MI.
- The findings suggest that increased arginase activity, as opposed to nitric oxide synthase, may be related to the presence of TCFA in heart lesions and a thicker int
There is a discrepancy between epicardial vessel patency and microcirculation perfusion in a third of patients treated with percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI). Optimization with aspiration thrombectomy (AT) may reduce distal embolization and microvascular obstruction. The effect of AT in the treatment of STEMI is debatable.
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- * It involved 139 patients over 65, focusing on their clinical and echocardiographic data, with a screening diagnosis of dementia based on specific cognitive test results.
- * Findings showed that older age and a specific measure (RWT) related to heart structure were independently linked to a higher likelihood of dementia, but RWT was only moderately effective for prediction.
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- This study examined the long-term effects of statin use on heart attack patients who also have cancer, analyzing data from over 1,000 patients treated between 2012 and 2017.
- Among 134 cancer patients, fewer were prescribed statins upon discharge compared to non-cancer patients (79.9% vs. 91.4%).
- The research found that not using statins after a heart attack significantly increased the risk of long-term mortality in both cancer and non-cancer patients.