Publications by authors named "Z-Q Liu"
Purpose: Inflammatory processes have been involved in diabetic retinopathy (DR). Interleukin (IL)-17A, a pro-inflammatory cytokine, is associated with DR occurrence and development. However, mechanisms underlying the IL-17A impact on DR need further investigations.
View Article and Find Full Text PDFBackground And Objectives: Randomized trials have proven the benefit of endovascular therapy (EVT) for acute large ischemic stroke. This study was to characterize the effect of time to treatment on benefit of EVT vs medical management (MM) among patients with large ischemic stroke.
Methods: This was a post hoc analysis of the Endovascular Therapy in Acute Anterior Circulation Large Vessel Occlusive Patients with a Large Infarct Core randomized trial.
Spodoptera litura (S. litura) is a polyphagous pest of the family Lepidoptera, which causes damage and yields losses to many crops. The long-term use of chemical pesticides for control not only seriously threatens environmental health, but also causes S.
View Article and Find Full Text PDFDevelopment of large-scale alkaline seawater electrolysis requires robust and corrosion-resistant anodes. Here we propose engineering NiFe layered double hydroxide (LDH)-based anodes by incorporating a series of anions into the LDH interlayers. The most optimal NiFe LDH anode with intercalated phosphates demonstrates stable operation at a high current density of 1.
View Article and Find Full Text PDFBackground And Objectives: Although dexmedetomidine (DEX) is widely administered during endovascular treatment (EVT) to enhance procedural adherence of patients with acute ischemic stroke (AIS) with large vessel occlusion, there is limited research on the association of DEX and outcomes among these patients. Hence, this study aimed to explore the safety and outcomes of DEX during conscious sedation (CS) in a real-world setting among patients undergoing EVT.
Methods: This study was an individual patient-level pooled analysis of 2 multicenter randomized clinical trials RESCUE-BT and DEVT.
Article Synopsis
- The study focuses on improving nanovaccines for COVID-19 by using icosahedral DNA origami particles to closely mimic the size and shape of the SARS-CoV-2 virus.
- By varying the arrangement and quantity of receptor binding domain (RBD) antigens on the DNA origami surface, researchers found that these modifications significantly enhance B cell activation.
- The optimized nanovaccines not only induce stronger and longer-lasting immune responses in female mouse models but also provide broader protection against various virus mutations compared to traditional mRNA vaccines.
Article Synopsis
- The study aimed to create a nomogram using ultrasound data to predict the aggressiveness of thyroid papillary carcinoma (PTC) by analyzing diverse radiomics features.
- A total of 471 patients were analyzed, with training and validation cohorts from different institutions, and various predictive factors such as age, nodule size, and elasticity measurements were used to develop the nomogram.
- The final nomogram showed strong predictive capabilities with AUC values exceeding 0.890 in different validation cohorts, indicating it outperformed traditional ultrasound methods and offers significant clinical utility.
Folds from fold: Exploring topological isoforms of a single-domain protein.
Proc Natl Acad Sci U S A
October 2024
Expanding the protein fold space beyond linear chains is of fundamental significance, yet remains largely unexplored. Herein, we report the creation of seven topological isoforms (i.e.
View Article and Find Full Text PDFBackground: Intraindividual variability in lipid profiles is recognized as a potential predictor of cardiovascular events. However, the influence of early adulthood lipid profile variability along with mean lipid levels on future coronary artery calcium (CAC) incidence remains unclear.
Methods: A total of 2395 participants (41.
Claudin18.2 has been recently recognized as a potential therapeutic target for gastric/gastroesophageal junction or pancreatic cancer. Here, we develop a Claudin18.
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- Metabolic dysfunction-associated steatohepatitis (MASH) complicates the delivery of therapeutic proteins due to excess extracellular matrix (ECM), leading to the development of a new treatment strategy called "Fibrosis overexpression and retention (FORT)."
- FORT utilizes specially designed retinoid-derivative lipid nanoparticles (LNPs) that enhance mRNA expression in fibrotic areas and include modifications to promote protein anchoring in the ECM.
- The approach has shown a tenfold increase in protein expression and improved retention of engineered therapeutic proteins in fibrotic lesions, proving effective in various animal models of MASH while reducing toxicity.
Article Synopsis
- * Analyzing data from 8,709 participants over five years, researchers found that increases in cognitive scores were tied to specific daily training durations.
- * Optimal CCT doses were determined to be 25-30 minutes per day for participants under 60 and 50-55 minutes for those 60 and older, indicating that the effectiveness of training varies with age.
Article Synopsis
- Primary familial brain calcification (PFBC) is a genetic neurological disorder with no current effective treatment, linked to mutations in the SLC20A2 gene.
- Researchers identified five new genetic variants in the SLC20A2 gene that disrupt normal splicing of its pre-mRNA, leading to dysfunctional protein production.
- The use of splice-switching antisense oligonucleotides (ASOs) not only helped restore functional SLC20A2 expression in affected cells but also showed promise in reducing brain calcification and controlling phosphorus levels in animal models, highlighting a potential therapeutic approach for PFBC.
Article Synopsis
- The evolution of SARS-CoV-2 variants highlights the need for multivalent vaccines, leading to the development of SCTV01E, a tetravalent COVID-19 vaccine targeting variants Alpha, Beta, Delta, and Omicron BA.1.
- A double-blind placebo-controlled trial showed SCTV01E had a vaccine efficacy of 69.4% against COVID-19 seven days post-vaccination, with higher efficacy rates in preventing symptomatic and all infections at 14 days.
- The vaccine demonstrated a significant neutralizing antibody response against Omicron BA.5 and had mild reactogenicity, indicating its potential effectiveness against emerging SARS-CoV-2 variants.
Article Synopsis
- Scientists discovered that problems with phosphate (Pi) levels in the brain can cause brain calcification and worsen brain damage.
- They found that certain genes, Pit2 and Xpr1, are really important for moving Pi in brain cells called astrocytes, which help control Pi levels.
- By fixing the problems with these genes in mice, they were able to reduce brain calcification, suggesting that boosting how astrocytes handle Pi could be a good way to help treat brain issues.
Basi-parallel anatomic scanning has been widely used for assessing the vascular morphology of vertebral basilar arteries. Previous studies have demonstrated its efficacy in evaluating the morphology of the MCA, which we refer to as MCA parallel anatomic scanning MR imaging (MCPAS). In this study, we present our experience with the application of MCPAS in patients with MCA occlusion.
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- - The study investigates the optimal duration of normobaric hyperoxia (NBO) treatment combined with endovascular therapy for patients suffering from acute ischemic stroke, conducted at Tianjin Huanhu Hospital with 100 participants randomly assigned to four treatment groups.
- - Results show that both the NBO-4h and NBO-6h groups exhibited a significant reduction in cerebral infarct volumes and improved stroke severity scores compared to the control, indicating that longer durations of NBO could enhance neuroprotection.
- - The trial found no significant differences in safety outcomes such as 90-day mortality rates and severe adverse events across all groups, suggesting that NBO therapy can be safely administered alongside standard treatments for ischemic stroke. *
Overexpression of vesicular stomatitis virus G protein (VSV-G) elevates the secretion of EVs known as gectosomes, which contain VSV-G. Such vesicles can be engineered to deliver therapeutic macromolecules. We investigated viral glycoproteins from several viruses for their potential in gectosome production and intracellular cargo delivery.
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- Asian soybean rust (ASR), caused by the fungus Phakopsora pachyrhizi, severely impacts soybean crops, with a lack of resistant varieties hindering effective management.
- Researchers isolated two genes, Rpp6907-7 and Rpp6907-4, from a resistant Chinese soybean landrace, which together provide broad-spectrum resistance to ASR.
- The study reveals that Rpp6907-7 is the primary gene conferring resistance, while Rpp6907-4 regulates its activity, indicating their potential in breeding improved soybean varieties.
Electrochemical research often requires stringent combinations of experimental parameters that are demanding to manually locate. Recent advances in automated instrumentation and machine-learning algorithms unlock the possibility for accelerated studies of electrochemical fundamentals via high-throughput, online decision-making. Here we report an autonomous electrochemical platform that implements an adaptive, closed-loop workflow for mechanistic investigation of molecular electrochemistry.
View Article and Find Full Text PDFU1 small nuclear RNA (snRNA) is an abundant and evolutionarily conserved 164-nucleotide RNA species that functions in pre-mRNA splicing, and it is considered to be a housekeeping non-coding RNA. However, the role of U1 snRNA in regulating host antiviral immunity remains largely unexplored. Here, we find that RNVU1-18, a U1 pseudogene, is significantly upregulated in the host infected with RNA viruses, including influenza and respiratory syncytial virus.
View Article and Find Full Text PDFThe emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariants BA.2.86 and JN.
View Article and Find Full Text PDFBackgrounds: Immune checkpoint blockade (ICB) is widely considered to exert long-term treatment benefits by activating antitumor immunity. However, many cancer patients show poor clinical responses to ICB due in part to the lack of an immunogenic niche. Focal adhesion kinase (FAK) is frequently amplified and acts as an immune modulator across cancer types.
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- A study evaluated the effectiveness and safety of intravenous tirofiban versus alteplase before endovascular treatment in patients with acute ischemic stroke caused by large vessel occlusion.
- Data was analyzed from two multicenter trials, comparing functional independence and safety outcomes like intracranial hemorrhage and mortality rates between the two treatment groups.
- Results indicated that tirofiban led to higher rates of functional independence compared to alteplase, and there were no significant differences in safety outcomes between the two treatments.
Purpose: To reveal the clinical significance, pathological involvement and molecular mechanism of imprinted in Prader-Willi syndrome (IPW) in RPE anomalies that contribute to AMD.
Methods: IPW expression under pathological conditions were detected by microarrays and qPCR assays. In vitro cultured fetal RPE cells were used to study the pathogenicity induced by IPW overexpression and to analyze its upstream and downstream regulatory networks.