Publications by authors named "Z-G Cui"
Genetic Landscape and Its Prognostic Impact in Children With Langerhans Cell Histiocytosis.
Arch Pathol Lab Med
February 2025
Article Synopsis
- Langerhans cell histiocytosis (LCH) is a rare cancer mainly affecting young children, and this study aimed to understand its genetic changes and how they relate to clinical outcomes.
- Researchers identified 30 genetic mutations in 5 key genes of the MAPK pathway in 83.9% of the pediatric patients studied, with BRAF V600E being the most common mutation.
- The presence of specific mutations was linked to different clinical features and survival rates, indicating that mutations like BRAF V600E are associated with more severe cases involving vital organs.
Background: Albeit considered with superior survival, around 30% of the early-stage non-squamous non-small cell lung cancer (Ns-NSCLC) patients relapse within 5 years, suggesting unique biology. However, the biological characteristics of early-stage Ns-NSCLC, especially in the Chinese population, are still unclear.
Methods: Multi-omics interrogation of early-stage Ns-NSCLC (stage I-III), paired blood samples and normal lung tissues (n=76) by whole-exome sequencing (WES), RNA sequencing, and T-cell receptor (TCR) sequencing were conducted.
Article Synopsis
- Functional nanostructures are essential for advanced technologies like plasmonics and biosensors, but achieving uniformity in their feature sizes over large areas is challenging due to traditional low-throughput nanopatterning methods.
- This research introduces a new lithographic approach that combines interference lithography with secondary exposure to precisely control feature sizes across large wafers, overcoming limitations of existing techniques.
- The team successfully produced 4-inch wafer-scale nanogratings with minimal linewidth variation and demonstrated the ability to create gradient grayscale colors by adjusting the filling ratio of the nanostructures.
Article Synopsis
- This article discusses the analysis of groomed jet substructure in proton-proton (pp) and lead-lead (Pb-Pb) collisions using the ALICE detector at a collision energy of 5.02 TeV.
- The study employs a soft drop grooming algorithm to isolate hard parton splittings and measures the groomed jet momentum splitting fraction and radius, revealing distinct behavior in jet structure under different collision conditions.
- Notably, a narrowing of the groomed jet radius distribution in Pb-Pb collisions suggests changes in jet angular structure due to quark-gluon plasma, while no significant differences are observed in momentum splitting fractions, contributing valuable insights into jet energy-loss mechanisms.
Purpose: To report three-decade changes of clinical characteristics, progress of treatments, and risk factors associated with mortality and enucleation in patients with retinoblastoma in China.
Design: Retrospective cohort study.
Methods: This multicenter study included 2552 patients diagnosed with retinoblastoma in 38 medical centers in 31 provinces in China from 1989 to 2017, with follow-up data.
Myocardial infarction (MI) is a leading cause of death worldwide for which there is no cure. Although cardiac cell death is a well-recognized pathological mechanism of MI, therapeutic blockade of cell death to treat MI is not straightforward. Death receptor 5 (DR5) and its ligand TRAIL [tumor necrosis factor (TNF)-related apoptosis-inducing ligand] are up-regulated in MI, but their roles in pathological remodeling are unknown.
View Article and Find Full Text PDFAim: To determine the safety of a higher starting dose of basal insulin in overweight/obese patients with type 2 diabetes (T2D).
Materials And Methods: This 16-week, randomized, multicentre, open-label trial enrolled adults with T2D (body mass index 25-40 kg/m ) and suboptimal glycaemic control (glycated haemoglobin [HbA1c] 7.5-11.
Article Synopsis
- Chronic inflammatory diseases, like atherosclerosis, feature persistent proinflammatory macrophages linked to dyslipidemia and oxidative stress, but the exact mechanisms connecting these factors to macrophage activation are not fully understood.
- The study aimed to explore how dyslipidemia and oxidative stress affect macrophage behavior through changes in immunometabolism and assessed potential therapies by targeting specific metabolic pathways.
- Findings indicate that oxidized LDL activates CD36, leading to a shift in mitochondrial metabolism that favors superoxide production over energy generation, resulting in inflammation and structural changes in macrophages that could be targeted for therapeutic purposes.
Several microRNAs (miRNAs) have been found expressed differentially in osteosarcoma (OS), so they may function in the onset and progression of OS. In this study, we found that miR-144 significantly suppresses osteosarcoma cell proliferation, migration, and invasion ability in vitro and inhibited tumor growth and metastasis in vivo. Mechanically, we demonstrated that Ras homolog family member A (RhoA) and its pivotal downstream effector Rho-associated, coiled-coil-containing protein kinase 1 (ROCK1) were direct targets of miR-144.
View Article and Find Full Text PDFPremature leaf senescence affects plant growth and yield in rice. NAD plays critical roles in cellular redox reactions and remains at a sufficient level in the cell to prevent cell death. Although numerous factors affecting leaf senescence have been identified, few involving NAD biosynthetic pathways have been described for plants.
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