Period 2 mutation accelerates ApcMin/+ tumorigenesis.

Colorectal cancer risk is increased in shift workers with presumed circadian disruption. Intestinal epithelial cell proliferation is gated throughout each day by the circadian clock. Period 2 (Per2) is a key circadian clock gene.

Galectin-3 expression in human atherosclerotic lesions.

The expression of galectin-3, a beta-galactoside-binding lectin, was studied in atherosclerotic lesions from specimens obtained from carotid endarterectomies, lower limb amputations, and thoracic aortas from autopsies of young adult trauma victims. Immunohistochemical staining with the monoclonal antibody M3/38 demonstrated the presence of galectin-3 in advanced atherosclerotic lesions from each of 13 cases of carotid endarterectomy and 16 lower limb amputations and in the thoracic aorta of 4 of 20 cases of trauma victim adults. Immunostaining did not detect galectin-3 in umbilical cord and normal thoracic aorta arteries and limb veins.

Recurrent basal cell carcinoma in margin-positive tumors.

The purpose of this investigation was (1) to determine the incidence of basal cell carcinoma (BCC) recurrence in patients who had microscopic evidence of residual tumor at the margin of resection and (2) to identify morphological characteristics that predispose to recurrence. Twenty-nine patients with margin-positive BCCs were found in a group of 339 patients who underwent BCC resection. Four patients were lost to follow-up.

Mixed cellular population in primary and metastatic periampullary adenocarcinoma of the duodenum: report of a case.

There are numerous reports on the mixed cellular population of primary tumors, especially in the gastrointestinal tract. However, reports of mixed cellular population in metastatic foci are rare. This is a report of a case of periampullary papillary adenocarcinoma of the duodenum with 4 types of cellular population.