A Scoping Review on Tyrosine Kinase Inhibitors in Cats: Current Evidence and Future Directions.

Tyrosine kinase inhibitors (TKIs) have become invaluable in the treatment of human and canine malignancies, but their role in feline oncology is less defined. While toceranib phosphate and masitinib mesylate are licensed for use in dogs, no TKI is yet approved for cats. This review systematically maps the research conducted on the expression of tyrosine kinases in neoplastic and non-neoplastic domestic feline tissues, as well as the in vitro/in vivo use of TKIs in domestic cats.

[Clinicopathologic characteristics, postoperative outcome, and prognostic factors in dogs with primary pulmonary carcinomas - A retrospective study of 61 dogs].

Introduction: Canine primary pulmonary carcinomas (PLC) are treated surgically. The goal of this study was to increase the veterinary database concerning clinical and pathological findings, postsurgical median survival times (mST), and prognostic factors in this tumor type.

Materials And Methods: Retrospective analysis of 61 dogs with 62 PLC treated surgically between 2007 and 2017.

Follow Up on Simple (Closed) Extraction of Fractured Maxillary Canine Teeth in Domestic Ferrets ().

Fractured canine teeth (especially maxillary canine teeth) are common in domestic ferrets (). We evaluated (detailed oral/dental and radiographic examination under general anesthesia) 18 domestic ferrets affected by 23 complicated crown fractures of periodontally healthy permanent maxillary canine teeth over a 2-year period. Average age of the ferrets at the time of diagnosis was 2.

Bactericidal activity of oral beta-lactam antibiotics in plasma and urine versus isogenic Escherichia coli strains producing broad- and extended-spectrum beta-lactamases.

Bacteria harbouring extended-spectrum beta-lactamases (ESBLs), derived by mutation from TEM-1, TEM-2 or SHV-1 beta-lactamases, have been described world-wide. The in vitro activities of these enzymes against beta-lactam antibiotics, including oral cephalosporins, are well recognised. The aim of this investigation was to assess the bactericidal activity of oral beta-lactam antibiotics available in Croatia (amoxicillin/clavulanate, cephalexin, cefuroxime, cefadroxil and ceftibuten), in biological fluids against isogenic Escherichia coli strains producing broad-spectrum (TEM-1, TEM-2 and SHV-1) and extended-spectrum beta-lactamases (SHV-2, SHV-3, SHV-4, SHV-5, SHV-12).