Publications by authors named "Z Zadik"
Unlabelled: To assess the long-term efficacy of burosumab for pediatric patients with X-linked hypophosphatemia, focusing on linear growth. This multi-center retrospective study included 35 pediatric patients who began treatment with burosumab between January 2018 and January 2021. We collected clinical data, anthropometric measurements, laboratory results, and Rickets Severity Score (RSS), from 2 years prior to treatment initiation and up to 4 years after.
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- Somatrogon, a long-acting human growth hormone, is tested as a weekly treatment for children with growth hormone deficiency in a 12-month study compared to daily GH (Genotropin).
- The study involved 53 prepubertal children, who were divided into groups receiving different doses of somatrogon or Genotropin, and many continued in a long-term safety and efficacy evaluation.
- Results showed significant improvements in annual height velocity and height standard deviation scores over the treatment period, with most side effects being mild and unrelated to the medication.
Aims: To determine the long-term risk of diabetes in a cohort of children treated with recombinant human growth hormone in Israel, using data from the Israeli National Diabetes Register.
Methods: Between 1988 and 2009, 2513 children were approved for growth hormone treatment. They were assigned to one of two groups.
Context: Daily injections are required for growth hormone (GH) replacement therapy, which may cause low compliance as a result of inconvenience and distress in patients.
Objective: C-terminal peptide-modified human GH (MOD-4023) is developed for once-a-week dosing regimen in GH-deficient (GHD) adults and children. The present trial was a safety and dose-finding study for weekly MOD-4023 in GHD children.
Context: The inconclusive evidence regarding long-term safety of recombinant human growth hormone (rhGH) therapy underlines the need for long-term large-scale cohorts.
Objective: To assess long-term mortality and cancer incidence among patients treated with rhGH during childhood in Israel.
Design: A population-based cohort study.