[Effect of benzonal and hyperbaric oxygenation on the intensity of the lipid peroxidation process and activity of the antioxidant system in patient with acute diffuse peritonitis].

Postsurgical patients with acute general peritonitis display clear disturbances in processes of lipid peroxidation and antioxidative defence. Conventional methods of treatment that have come to be used in the postoperative period to deal with the trouble do not permit achieving an optimum result. Supplementation of the complex of therapeutic measures with hyperbaric oxigenation appeared to have an insignificant effect on the parameters under study.

[Efficiency of sorption therapy with the enterosorbent BC-1 in experimental hypercholesterolemia].

A hypercholesterolemic effect has been examined of the enterosorbent BC-1 capable of binding cholesterol from the standardized solution and bile in in vitro experiments in rats with induced hypercholesterolemia. The results secured suggest to us a high sorption capability of the new sorbent with respect to cholesterol.

[Effect of benzonal on the absorptive-secretory function in the liver of immature rabbits in post-compression period of long-term compression syndrome].

The absorptive-secretory function of hepatocytes using chromodiagnostic test by means of cardiogrin in rabbits at the age of 1 month in postcompression period of prolonged compression syndrome (PCS) was studied. It was established that the given function of hepatocytes was sufficiently and stably depressed for PCS. By effect of inductor of hepatocytes' monooxygenase system benzonal the disorders in parameters of cardiogreen pharmacokinetics are being distinctly removed.

[The liver monooxygenase system activity in the long-term compression syndrome and treatment with benzonal in prepubertal rats and rabbits].

A compression syndrome was reproduced in rats and rabbits aged one month. Efficacy of the benzonal treatment in the postcompression period was evaluated by measuring the parameters of antipyrin pharmacokinetics, hexenal sleep duration, and the level of medium-molecular-weight (MMW) peptides in the blood serum. It was established that benzonal restored the detoxicating liver function (significantly reduced in animals with the compression syndrome) and eliminated the pronounced endotoxemia manifestations.

[Phytin efficacy in correction of the impaired detoxication liver function in the long-term compression syndrome in rats in prepubertal period].

The compression syndrome was reproduced in rats aged one month and the efficacy of phytin in correcting the activity infringement and restoring the content of basic components of the hepatocyte monooxygenase enzyme system was studied in the postcompression period. The compression led to pronounced inhibition of the activity of aniline hydroxylase and amidopyrine M-demethylase, reduced the content of liver microsomal protein and cytochromes P-450 and b5, and increased the level of medium- molecular-weight (MMW) peptides in the blood serum. A six-day treatment with phytin restored the normal level of the liver monooxygenase system components and MMW peptides.