[Mechanisms of the inotropic action of nonachlazine].

It has been demonstrated clinically and experimentally that administration of nonachlazine enhances myocardial contractility because of the stimulation of beta-adrenostructures and that the initial status of the latter ones determines in many respects the drug action intensity.

[Functional state of the myocardium during stenocardia induced by isoproterenol].

Hemodynamic changes in healthy subjects versus patients with chronic coronary heart disease are compared. In cases of isoproterenol caused tachycardia, the patients developing angina showed a less prominent beneficial inotropic effect as compared with healthy subjects and angina-free patients. The initiation of drug infusion led to a marked increase in the rheographic index of myocardial contractility; however, already in the initial stages of ST segment depression, this parameter was characterized by a reversed time-course which progressed with the increasing electrocardiographic signs of myocardial ischemia.

[Energy homeostasis and natural biological models].

Phase analysis of cardiac cycle was performed in normal subjects of both sexes aged 18-20 years at winter and summer seasons. It was found that the energy dependent systolic phases (isometric contraction, period of expulsion) have a definite continuance in connection with energy background, typological and sexual features of the homeostasis. The data evidence that the systolic phases can be considered as informative model for the study of energy homeostasis.