Multi-Criteria Evaluation for Sorting Motion Planner Alternatives.

Automated vehicles are expected to push towards the evolution of the mobility environment in the near future by increasing vehicle stability and decreasing commute time and vehicle fuel consumption. One of the main limitations they face is motion sickness (MS), which can put their wide impact at risk, as well as their acceptance by the public. In this direction, this paper presents the application of motion planning in order to minimise motion sickness in automated vehicles.

Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile: A pooled analysis.

Background: The diagnosis of type 2 diabetes (T2D) in younger adults, an increasingly common public health issue, is associated with a higher risk of cardiovascular complications and mortality, which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.

Aim: To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.

Methods: A pooled dataset was used, comprised of data from five previous studies of adults with T2D, including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.

Clinical associations with stage B heart failure in adults with type 2 diabetes.

Background: There is a high prevalence of asymptomatic (American Heart Association Stage B) heart failure (SBHF) in people with type 2 diabetes (T2D). We aimed to identify associations between clinical characteristics and markers of SBHF in adults with T2D, which may allow therapeutic interventions prior to symptom onset.

Methods: Adults with T2D from a multi-ethnic population with no prevalent cardiovascular disease [ = 247, age 52 ± 12 years, glycated haemoglobin A1c (HbA1c) 7.

Effects of liraglutide versus sitagliptin on circulating cardiovascular biomarkers, including circulating progenitor cells, in individuals with type 2 diabetes and obesity: Analyses from the LYDIA trial.

The mechanisms behind the beneficial cardiovascular effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) compared with dipeptidyl peptidase-4 inhibitors (DPP4is) remain largely unknown, despite both targeting the incretin pathway to improve glycaemic control. In these prespecified secondary analyses of the LYDIA trial, we examined the impact of the GLP-1RA liraglutide (1.8 mg once-daily) and the DPP4i sitagliptin (100 mg once-daily) on circulating cardiovascular biomarkers associated with atherosclerotic risk, including circulating progenitor cells (CPCs).

Cardiovascular Determinants of Aerobic Exercise Capacity in Adults With Type 2 Diabetes.

Objective: To assess the relationship between subclinical cardiac dysfunction and aerobic exercise capacity (peak VO) in adults with type 2 diabetes (T2D), a group at high risk of developing heart failure.

Research Design And Methods: Cross-sectional study. We prospectively enrolled a multiethnic cohort of asymptomatic adults with T2D and no history, signs, or symptoms of cardiovascular disease.