Oxyresveratrol as a novel ferroptosis inducer exhibits anticancer activity against breast cancer via the EGFR/PI3K/AKT/GPX4 signalling axis.

Introduction: Oxyresveratrol (ORes) exhibits significant anticancer activity, particularly against breast cancer. However, its exact mechanism of action (MOA) remains unclear. This study aimed to investigate the pharmacological activity and underlying MOA.

Prediction of posthepatectomy liver failure in patients with hepatocellular carcinoma through ultrasound elastography.

In this article, we comment on the article by Cheng published in recently. Posthepatectomy liver failure (PHLF) remains a leading cause of hepatectomy-related mortality and can be evaluated according to liver reserve function. Liver stiffness (LS) measured by ultrasonic elastography and spleen area demonstrate a strong correlation with hepatic proliferation, fibrosis, and portal vein congestion, thus indirectly reflecting liver reserve function.

ALKBH5 alleviates lower extremity arteriosclerosis by regulating ITGB1 demethylation and influencing macrophage polarization.

Objective: M6A methylation-regulated macrophages play an important role in the occurrence and development of arteriosclerosis. However, their role in lower extremity arteriosclerosis remains unclear. Therefore, this study aims to explore the key factors that regulate arteriosclerosis methylation in the lower extremities and the mechanism by which they affect arteriosclerosis by influencing macrophage polarization.

Ply Optimization of Composite Laminates for Processing-Induced Deformation and Buckling Eigenvalues Based on Improved Genetic Algorithm.

The structure of thermoset composite laminated plates is made by stacking layers of plies with different fiber orientations. Similarly, the stiffened panel structure is assembled from components with varying ply configurations, resulting in thermal residual stresses and processing-induced deformations (PIDs) during manufacturing. To mitigate the residual stresses caused by the geometric features of corner structures and the mismatch between the stiffener-skin ply orientations, which lead to PIDs in composite-stiffened panels, this study proposes a multi-objective stacking optimization strategy based on an improved adaptive genetic algorithm (IAGA).