Publications by authors named "Z Yousefi"
Liver fibrosis (LF) is a clinical disorder characterized by inflammation and excessive accumulation of extracellular matrix (ECM). This study investigates the effects of the antifibrotic compound pirfenidone (PFD) on improving LF through histological changes and modulation of eukaryotic translation initiation factor 6 (eIF6), P311, and transforming growth factor beta (TGF-β) in rats with bile duct ligation (BDL)-induced LF. Rats received daily doses of PFD (200 and 500 mg/kg) for 4 weeks.
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- The study focuses on granulosa cell tumors (GCTs), identifying their clinical significance and recurrence challenges despite treatment advancements.
- The research involved a retrospective analysis of 92 patients with GCTs, showing that most were under 50 years old and presented with symptoms like pain and abnormal bleeding; it recorded a high five-year overall survival rate of 98.2%.
- Key findings highlight that stage IV is a significant predictor of recurrence, emphasizing the importance of staging in prognosis and supporting fertility-sparing surgery for early-stage patients.
Effectiveness of Ellis's Rational-Emotional Approach on Criminal Thinking and Law-Evasion in Male Prisoners.
Int J Offender Ther Comp Criminol
October 2024
This study aimed to investigate the effectiveness of Ellis's rational-emotional approach on criminal thinking and law-evasion in male prisoners. A quasi-experimental design utilizing pretest, post-test, and follow-up test and waiting-list control groups was conducted. Thirty male prisoners were selected by purposeful sampling and randomized into experimental and waiting list control groups.
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- - The study explores the connection between microRNA miR-141, Sirtuin 1 (SIRT1), and non-alcoholic fatty liver disease (NAFLD) in adults, finding significant changes in these factors related to obesity and metabolic health.
- - In a group of 100 adults, it was revealed that miR-141 levels were higher and SIRT1 expression was lower in those with obesity compared to normal-weight individuals, indicating a negative relationship between the two.
- - The findings suggest that increased miR-141 could inhibit SIRT1, leading to obesity-related issues like NAFLD, highlighting the potential of miR-141 as a target for diagnosis and treatment in these conditions.
Reproductive health needs of HIV serodiscordant couples: a systematic review.
Front Public Health
September 2024
Objectives: HIV is closely linked to reproductive and sexual health. HIV Serodiscordant couples face significant social, reproductive, and sexual challenges. This systematic review aimed to identify their reproductive health needs.
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