Comprehensive Genetic Profile of Chinese Muscle-Invasive Bladder Cancer Cohort.

Objective: The aim of our study was to characterize the spectrum of mutations in muscle-invasive bladder cancer (MIBC) in the Chinese population, identifying mutational features and exploring potential therapeutic targets.

Methods: We collected samples from 62 Chinese patients with MIBC. For each patient, tumor tissues or blood samples were collected and sequenced by whole exome sequencing.

Machine learning in public health informatics: evidence that complex sampling structures may not be needed for prediction models with imbalanced outcomes.

Purpose: The objective of this study is to investigate the predictive ability of machine learning models for imbalanced outcomes from national survey data without the use of sampling weights.

Methods: We evaluated the predictive performance of machine learning models on imbalanced outcomes from the US National Health and Nutrition Examination Survey (USNHANES) without using sampling weights. Four machine learning models (support vector machine, random forest, least absolute shrinkage and selection operator regression, and deep neural network) were compared with a logistic model that incorporates the survey's complex sampling design.

Myosin light chain 9 mediates graft fibrosis after pediatric liver transplantation through TLR4/MYD88/NF-κB signaling.

Background & Aims: The incidence of graft fibrosis is elevated following pediatric liver transplantation (pLT) and is influenced by cold ischemic time (CIT). Myosin light chain 9 (MYL9), a member of the myosin family, could act on hepatic stellate cells (HSCs) and induce a transition to active phase. We hypothesized that cold ischemic injury could stimulate MYL9 expression and lead to graft fibrosis.

Study of Water Resistance of Polyurethane Coatings Based on Microanalytical Methods.

This study investigates the effect of microstructural changes in polyurethane coatings on their water resistance properties. Polyurethane coatings with varying diluent contents were prepared and tested for water penetration resistance and mechanical property retention. The time-dependent behavior of water within the coatings at different immersion durations was analyzed using low-field nuclear magnetic resonance (NMR).

Electrolyte Decoupling Strategy for Metal Oxide-Based Zinc-Ion Batteries Free of Crosstalk Effect.

The crosstalk of transition metal ions between the metal oxide cathode and Zn anode restricts the practical applications of aqueous zinc-ion batteries (ZIBs). Herein, we propose a decoupled electrolyte (DCE) consisting of a nonaqueous-phase (N-phase) anolyte and an aqueous-phase (A-phase) catholyte to prevent the crosstalk of Mn, thus extending the lifespan of MnO-based ZIBs. Experimental measurements and theoretical modelling verify that trimethyl phosphate (TMP) not only synergistically works with NHCl in the N-phase anolyte to enable fast Zn conduction while blocking Mn diffusion toward anode, but also modifies the Zn solvation structure to suppress the dendrite formation and corrosion on Zn anode.