Competency-based ultrasound curriculum for standardized training resident: a pre- and post-training evaluation.

Background: Ultrasound training is crucial for residents across specialties but presents challenges for residents that are not specializing in ultrasound. Investigating the effectiveness of competency-based ultrasound curricula for a wider range of medical specialties is imperative.

Methods: A total of 250 residents who attended the ultrasound curriculum between June 2023 and June 2024 were included in the analysis.

Piperidine and bis-piperidine alkaloids from the peels of Areca catechu and their monoamine oxidases inhibitory activity.

Eleven undescribed piperidine alkaloids, arecachines A‒J (1‒11), were isolated from the peels of Areca catechu. Compounds 8‒11 are featured as bis-piperidine alkaloids. Their structures were elucidated by analysis of UV, IR, HRESIMS, 1D and 2D NMR spectra.

Multi-omics analysis reveals the role of UGT72 family genes in arbutin biosynthesis in Pyrus and evolution driven by whole genome duplication.

The UGT72 gene family encodes proteins that glycosylate phenylpropanoids, and thus contribute to the synthesis of various phenolic substances. However, their functional role and evolutionary history in Pyrus spp. remains poorly understood.

Co-integration of laccase and xylanase from Bacillus pumilus into mini-cellulosome facilitates softwood sulfite pulp biobleaching and reduces hydrogen peroxide consumption.

Biobleaching is an eco-friendly strategy that can reduce costs and pollution in the pulp and paper industry. Herein, an effective biobleaching approach was proposed using a novel multi-enzyme complex. The multi-enzyme complex was constructed based on mini-cellulosome scaffolding protein integrated with laccase (BpLac) and xylanase (BpXyn) from Bacillus pumilus.

A versatile and automatic on-line screening method: Transverse diffusion of laminar flow profiles-based capillary electrophoresis for exploring PTP1B inhibitors in natural products.

Natural products (NPs) play an important role in drug discovery and drug development due to their diverse chemical properties and biological activities. In the present work, an on-line capillary electrophoresis (CE) method was developed and applied to screen protein tyrosine phosphatase 1B (PTP1B) inhibitors in NPs. As a generic technique, transverse diffusion of laminar flow profiles (TDLFP) was utilized to mix all reactants in the capillary for on-line enzymatic reaction.