Bola-Amphiphilic Dendrimer Enhances Imatinib to Target Metastatic Ovarian Cancer via β-Catenin-HRP2 Signaling Axis.

Ovarian cancer is the leading cause of death among all gynecological malignancies, and drug resistance renders the current chemotherapy agents ineffective for patients with advanced metastatic tumors. We report an effective treatment strategy for targeting metastatic ovarian cancer involving a nanoformulation (Bola/IM)─bola-amphiphilic dendrimer (Bola)-encapsulated imatinib (IM)─to target the critical mediator of ovarian cancer stem cells (CSCs) CD117 (c-Kit). Bola/IM offered significantly more effective targeting of CSCs compared to IM alone, through a novel and tumor-specific β-catenin/HRP2 axis, allowing potent inhibition of cancer cell survival, stemness, and metastasis in metastatic and drug-resistant ovarian cancer cells.

Carbon Defects as Highly Active Sites for Gold Detection and Recovery.

The use of precious metals (PMs) in many areas, such as printed circuit boards, catalysts, and target drugs, is increasing due to their unique physical and chemical properties, but their recovery remains a great challenge in terms of zero-valent PMs as final product. We report a highly hydrophilic carbon dot (CD) as reductant (electron donor), the defects in CD served as efficient active sites for zero-valent PMs recovery with an electron-donating capacity is ~1.7 mmol g-1.

Expert consensus on apical microsurgery.

Apical microsurgery is accurate and minimally invasive, produces few complications, and has a success rate of more than 90%. However, due to the lack of awareness and understanding of apical microsurgery by dental general practitioners and even endodontists, many clinical problems remain to be overcome. The consensus has gathered well-known domestic experts to hold a series of special discussions and reached the consensus.

Exploring symptom clusters and core symptoms during the vulnerable phase in patients with chronic heart failure: a network-based analysis.

Aims: To construct a symptom network of chronic heart failure patients in the vulnerable period and identify core symptoms and bridge symptoms between different symptom clusters.

Methods And Results: A convenience sampling method was used to select 402 patients with chronic heart failure within 3 months after discharge from the cardiology departments of two tertiary-level A hospitals in Zhenjiang City, and symptom-related entries of the Minnesota living with heart failure questionnaire (MLHFQ) were used to conduct the survey. Symptom networks were constructed using the R language.

High-performance solid-state electrochemical thermal switches with earth-abundant cerium oxide.

Thermal switches, which electrically turn heat flow on and off, have attracted attention as thermal management devices. Electrochemical reduction/oxidation switches the thermal conductivity (κ) of active metal oxide films. The performance of the previously proposed electrochemical thermal switches is low; the on/off κ-ratio is mostly less than 5, and the κ-switching width is less than 5 watts per meter kelvin.