-Ge/B 1,1-Hydroboration of Alkynylgermanes with 9-BBN.

A 1,1-hydroboration of alkynylgermanes with unique -Ge/B stereochemistry under transition-metal-free conditions is reported. Mechanistic studies suggest that a pathway involving α-boration followed by a stepwise 1,2-Ge/H shift on the intermediate structurally lies between an alkyne-Ge π complex and a typical vinyl cation. The resulting Ge/B bimetallic modules, along with a /Ge/B trimetallic variant, can be conveniently transformed into trisubstituted olefins through iterative divergent cross-coupling.

Effects of lipopolysaccharide infusion on feed intake, apparent digestibility, rumen fermentation and microorganisms of young Holstein bulls fed diets with different ratios of lysine and methionine.

The aim of this experiment was to investigate the effects of intravenous infusion of lipopolysaccharide (LPS) and feeding different ratios of lysine (Lys) and methionine (Met) on feed intake, apparent digestibility, rumen fermentation and microorganisms in young Holstein bulls. Five seven-month-old Holstein bulls with similar body weights (279 ± 42 kg) were selected and subjected to a 5 × 5 Latin square experiment. The control group (CON) was fed with basal diet and the ratio of Lys to Met in the diet was adjusted to 3.

Establishment of an HPLC Fingerprint and Cluster Analysis for Miao Ethnic Medicine .

, a traditional Miao medicine, is commonly used by the renowned national-level Chinese Traditional Medicine practitioner Zhengshi Wu for the treatment of diarrhea due to its strong antioxidative, anti-inflammatory, and antidiarrheal effects. This study aimed to establish a high-performance liquid chromatography (HPLC) fingerprint for to provide new evidence and technical means for the scientific evaluation and effective quality control of . The procedure involved isolation with a Nano ChromCore C18 column (250 mm × 4.

Dual-responsive micromotor pill for targeted retention in the intestines .

There has been considerable interest in the recent advances in synthetic micro/nanomotors in diverse biofluids due to their potential biomedical applications. However, the propulsion of existing micro/nanomotor platforms for delivery in the gastrointestinal (GI) tract is inefficient. Herein, we present a magnetically and chemically actuated micromotor-tableted pill that can be actively retained in the GI tract .

Signal integrator function of CXXC5 in Cancer.

CXXC type zinc finger protein 5 (CXXC5) is a member of the ZF-CXXC family and plays a pivotal role in signal integration and information transfer within cell signaling network. CXXC5 acts as a regulator in various physiological processes, and abnormalities in its protein structure or function have been linked to multiple pathological processes. In this article, we correspondingly describe the composition of the ZF-CXXC family, emphatically introducing the features of the CXXC5 gene and protein, review the role of CXXC5 in cellular signaling networks, the physiological and pathological processes associated with CXXC5 dysregulation, and particularly focus on the correlation between CXXC5 and cancers.