Publications by authors named "Z W Hawks"
Introduction: Associations between amyloid-tau-neurodegeneration (ATN) plasma biomarkers and cognition have not been characterized in adults with type 1 diabetes (T1D).
Methods: Using data from participants in the Glycemic Variability and Fluctuations in Cognitive Status in Adults with T1D (GluCog) study ( = 114), we evaluated associations between phosphorylated tau (pTau)181, pTau217, β-amyloid 42/40 ratio, glial fibrillary acidic protein (GFAP), and neurofilament light (NfL) and self-administered digital cognitive tests, adjusting for age, sex, education, comorbidities (e.g.
Type 1 diabetes (T1D) is a chronic condition characterized by glucose fluctuations. Laboratory studies suggest that cognition is reduced when glucose is very low (hypoglycemia) and very high (hyperglycemia). Until recently, technological limitations prevented researchers from understanding how naturally-occurring glucose fluctuations impact cognitive fluctuations.
View Article and Find Full Text PDFObjective: Individuals with type 1 diabetes (T1D) have increased risk for cognitive dysfunction and high rates of sleep disturbance. Despite associations between glycemia and cognitive performance using cross-sectional and experimental methods few studies have evaluated this relationship in a naturalistic setting, or the impact of nocturnal versus daytime hypoglycemia. Ecological Momentary Assessment (EMA) may provide insight into the dynamic associations between cognition, affective, and physiological states.
View Article and Find Full Text PDFArticle Synopsis
- Traditional cognitive assessments often measure performance at just one point in time, which can overlook how cognitive abilities change due to various factors like environment and health conditions, making these assessments less reliable for certain populations, like individuals with type 1 diabetes (T1D).
- The study aimed to validate a new method called ecological momentary assessment (EMA) to track cognitive performance over time in both adults with T1D and a general community sample, measuring their performance multiple times daily across several days.
- Results showed that cognitive EMA has high reliability and validity, effectively capturing both individual differences and fluctuations in cognitive performance within individuals, proving to be a useful tool for understanding cognitive variations in real-world settings.
Accurate Prediction of Momentary Cognition From Intensive Longitudinal Data.
Biol Psychiatry Cogn Neurosci Neuroimaging
August 2023
Background: Deficits in cognitive performance are implicated in the development and maintenance of psychopathology. Emerging evidence further suggests that within-person fluctuations in cognitive performance may represent sensitive early markers of neuropsychiatric decline. Incorporating routine cognitive assessments into standard clinical care-to identify between-person differences and monitor within-person fluctuations-has the potential to improve diagnostic screening and treatment planning.
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