Quantitative relationships between elastic modulus of rod and biomechanical properties of transforaminal lumbar interbody fusion: a finite element analysis.

Background: Currently, some novel rods with lower elastic modulus have the potential as alternatives to traditional titanium alloy rods in lumbar fusion. However, how the elastic modulus of the rod (rod-E) influences the biomechanical performance of lumbar interbody fusion remains unclear. This study aimed to explore the quantitative relationships between rod-E and the biomechanical performance of transforaminal lumbar interbody fusion (TLIF).

Controllable tip exposure of ultramicroelectrodes coated by diamond-like carbon via direct microplasma jet for enhanced stability and fidelity in single-cell recording.

Precise and long-term electroanalysis at the single-cell level is crucial for the accurate diagnosis and monitoring of brain diseases. The reliable protection in areas outside the signal acquisition points at sharp ultramicroelectrode (UME) tips has a significant impact on the sensitivity, fidelity, and stability of intracellular neural signal recording. However, it is difficult for existing UMEs to achieve controllable exposure of the tip functional structure, which affects their ability to resist environmental interference and shield noise, resulting in unsatisfactory signal-to-noise ratio and signal fidelity of intracellular recordings.

Sensitive and high-throughput isomer-specific analysis of human milk oligosaccharides using UPLC-MS/MS and its application to secretor status assignment.

Human milk oligosaccharides (HMOs) are now the principal component of the latest infant formula generation. However, it is challenging to separate and quantify highly heterogeneous isomers when analyzing HMOs. Here, we developed a high-throughput isomer-resolved quantification method for 21 native HMOs based on ultrahigh-performance liquid chromatography-mass spectrometry-multiple reaction monitoring (UPLC-MS-MRM) technology.

Comprehensive Chlorine Suppression: Advances in Materials and System Technologies for Direct Seawater Electrolysis.

Seawater electrolysis offers a promising pathway to generate green hydrogen, which is crucial for the net-zero emission targets. Indirect seawater electrolysis is severely limited by high energy demands and system complexity, while the direct seawater electrolysis bypasses pre-treatment, offering a simpler and more cost-effective solution. However, the chlorine evolution reaction and impurities in the seawater lead to severe corrosion and hinder electrolysis's efficiency.

Whole Transcriptome-Wide Analysis Combined with Summarydata-Based Mendelian Randomization Identifies High-Riskgenes for Cholelithiasis Incidence.

Background: Cholelithiasis is influenced by various factors, including genetic elements identified in genome-wide association studies (GWAS), but their biological functions are not fully understood.

Methods: Analyzing data from the Finngen database with 37,041 cholelithiasis cases and 330,903 controls, this study combined SNP data from GTEx v8 and linkage disequilibrium data from the 1000 Genomes Project. Using the TWAS FUSION protocol and SMR analysis, it investigated the relationship between gene expression and cholelithiasis, employing colocalization tests and conditional analyses to explore causality.